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Klhl14 kelch-like family member 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364823, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl14provided by RGD
Official Full Name
kelch-like family member 14provided by RGD
Primary source
RGD:1566178
See related
EnsemblRapid:ENSRNOG00000015418 AllianceGenome:RGD:1566178
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566178
Summary
Predicted to be located in actin cytoskeleton; aggresome; and cytosol. Predicted to be active in endoplasmic reticulum; neuron projection; and neuronal cell body. Orthologous to human KLHL14 (kelch like family member 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 50.9), Spleen (RPKM 25.8) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl14 in Genome Data Viewer
Location:
18p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (13079159..13192728, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (12804253..12917828, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (12526627..12640381, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098265 Neighboring gene GRB2 associated regulator of MAPK1 subtype 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RIKEN cDNA 4930426D05 gene like Neighboring gene uncharacterized LOC134482977 Neighboring gene coiled-coil domain containing 178 Neighboring gene ASXL transcriptional regulator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. Giles LM, et al. J Biol Chem, 2009 Aug 7. PMID 19535332, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in aggresome IEA
Inferred from Electronic Annotation
more info
  
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 14
Names
kelch-like 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108885.1 → NP_001102355.1  kelch-like protein 14

    See identical proteins and their annotated locations for NP_001102355.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473974
    UniProtKB/TrEMBL
    A0A2I4HY32, A0A5S6R9P2, A0A8I6APG0, A6J2H6, D3ZYQ7
    Related
    ENSRNOP00000020697.5, ENSRNOT00000020697.8
    Conserved Domains (4) summary
    PHA03098
    Location:140 → 602
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:365 → 412
    Kelch; KELCH repeat [structural motif]
    cd18243
    Location:1 → 190
    BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
    cd18453
    Location:183 → 284
    BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    13079159..13192728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096999.2 → XP_038952927.1  kelch-like protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A2I4HY32, A0A5S6R9P2, A0A8I6APG0, A6J2H6, D3ZYQ7
    Related
    ENSRNOP00000107410.1, ENSRNOT00000123493.1
    Conserved Domains (4) summary
    PHA03098
    Location:140 → 602
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:365 → 412
    Kelch; KELCH repeat [structural motif]
    cd18243
    Location:1 → 190
    BTB_POZ_KLHL14_printor; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14)
    cd18453
    Location:183 → 284
    BACK_KLHL14; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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