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Ctif cap binding complex dependent translation initiation factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 364900, updated on 2-Nov-2024

Summary

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Official Symbol
Ctifprovided by RGD
Official Full Name
cap binding complex dependent translation initiation factorprovided by RGD
Primary source
RGD:1311887
See related
EnsemblRapid:ENSRNOG00000018342 AllianceGenome:RGD:1311887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gm672
Summary
Predicted to enable translation activator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of translational initiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human CTIF (cap binding complex dependent translation initiation factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 102.8), Brain (RPKM 52.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ctif in Genome Data Viewer
Location:
18q12.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (71331222..71602493, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (69056151..69327454, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (71467381..71701423, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556053 Neighboring gene SMAD family member 7 Neighboring gene uncharacterized LOC120098120 Neighboring gene peroxisomal biogenesis factor 19-like Neighboring gene uncharacterized LOC102548225 Neighboring gene uncharacterized LOC120098205 Neighboring gene uncharacterized LOC134483052 Neighboring gene uncharacterized LOC102556385 Neighboring gene zinc finger and BTB domain containing 7C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Kim KM, et al. Genes Dev, 2009 Sep 1. PMID 19648179, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CBP80/20-dependent translation initiation factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108891.2 → NP_001102361.2  CBP80/20-dependent translation initiation factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    Related
    ENSRNOP00000071241.2, ENSRNOT00000088662.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    71331222..71602493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097004.2 → XP_038952932.1  CBP80/20-dependent translation initiation factor isoform X3

    UniProtKB/TrEMBL
    D3ZD47
    Related
    ENSRNOP00000107893.1, ENSRNOT00000155127.1
    Conserved Domains (1) summary
    pfam02854
    Location:379 → 579
    MIF4G; MIF4G domain

  2. XM_063277493.1 → XP_063133563.1  CBP80/20-dependent translation initiation factor isoform X3

    Related
    ENSRNOP00000094890.2, ENSRNOT00000098958.2

  3. XM_039097008.2 → XP_038952936.1  CBP80/20-dependent translation initiation factor isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ79, D3ZD47
    Conserved Domains (1) summary
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  4. XM_063277494.1 → XP_063133564.1  CBP80/20-dependent translation initiation factor isoform X4

  5. XM_039097007.2 → XP_038952935.1  CBP80/20-dependent translation initiation factor isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ79, D3ZD47
    Related
    ENSRNOP00000024716.8, ENSRNOT00000024716.8
    Conserved Domains (1) summary
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  6. XM_039097006.2 → XP_038952934.1  CBP80/20-dependent translation initiation factor isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ79, D3ZD47
    Conserved Domains (1) summary
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  7. XM_039097010.2 → XP_038952938.1  CBP80/20-dependent translation initiation factor isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ79, D3ZD47
    Conserved Domains (1) summary
    pfam02854
    Location:402 → 602
    MIF4G; MIF4G domain

  8. XM_039097003.1 → XP_038952931.1  CBP80/20-dependent translation initiation factor isoform X1

    UniProtKB/TrEMBL
    D3ZD47
    Conserved Domains (1) summary
    pfam02854
    Location:400 → 600
    MIF4G; MIF4G domain
Nucleotide Protein Strain
Heading Accession and Version

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