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St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364901, updated on 10-Jul-2024

Summary

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Official Symbol
St8sia5provided by RGD
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by RGD
Primary source
RGD:1302934
See related
EnsemblRapid:ENSRNOG00000022691 AllianceGenome:RGD:1302934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SATV; SIAT8E; SIAT8-E; ST8SiaV
Summary
Enables sialyltransferase activity. Involved in glycosphingolipid biosynthetic process. Located in Golgi membrane. Orthologous to human ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 83.1), Muscle (RPKM 36.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See St8sia5 in Genome Data Viewer
Location:
18q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73010235..73072984)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70736395..70802537)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73564010..73630256)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483057 Neighboring gene haloacid dehalogenase-like hydrolase domain containing 2 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene protein inhibitor of activated STAT, 2 Neighboring gene uncharacterized LOC102552068 Neighboring gene uncharacterized LOC102551787 Neighboring gene lipoxygenase homology PLAT domains 1 Neighboring gene uncharacterized protein DDB_G0292186-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The c-series gangliosides GT3, GT2 and GP1c are formed in rat liver Golgi by the same set of glycosyltransferases that catalyse the biosynthesis of asialo-, a- and b-series gangliosides. Iber H, et al. Glycobiology, 1992 Apr. PMID 1606358
  2. Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3. Kono M, et al. J Biol Chem, 1996 Nov 15. PMID 8910600
  3. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. Bailey MJ, et al. J Biol Chem, 2009 Mar 20. PMID 19103603, Free PMC Article
  4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of St8sia5 increases over 15 fold at night in the rat pineal gland.
    Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-2,8-sialyltransferase 8E
Names
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 5
sialyltransferase 8E
sialyltransferase St8Sia V
NP_001400037.1
NP_998793.2
XP_038952939.1
XP_038952940.1
XP_038952941.1
XP_038952943.1
XP_063133565.1
XP_063133566.1
XP_063133567.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413108.1 → NP_001400037.1  alpha-2,8-sialyltransferase 8E isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018

  2. NM_213628.2 → NP_998793.2  alpha-2,8-sialyltransferase 8E isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    A0A0G2JV41, E9PU47, Q6ZXC8
    Related
    ENSRNOP00000107226.1, ENSRNOT00000165782.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    73010235..73072984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097012.2 → XP_038952940.1  alpha-2,8-sialyltransferase 8E isoform X2

    Related
    ENSRNOP00000033363.2, ENSRNOT00000035317.3
    Conserved Domains (1) summary
    pfam00777
    Location:118 → 371
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_039097011.2 → XP_038952939.1  alpha-2,8-sialyltransferase 8E isoform X1

    Related
    ENSRNOP00000069340.2, ENSRNOT00000077679.3
    Conserved Domains (1) summary
    pfam00777
    Location:154 → 407
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_063277495.1 → XP_063133565.1  alpha-2,8-sialyltransferase 8E isoform X3

  4. XM_063277496.1 → XP_063133566.1  alpha-2,8-sialyltransferase 8E isoform X4

  5. XM_063277497.1 → XP_063133567.1  alpha-2,8-sialyltransferase 8E isoform X5

  6. XM_039097013.2 → XP_038952941.1  alpha-2,8-sialyltransferase 8E isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:63 → 316
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_039097015.2 → XP_038952943.1  alpha-2,8-sialyltransferase 8E isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:44 → 297
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZXC8.2 GenPept UniProtKB/Swiss-Prot:Q6ZXC8

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