Epg5 ectopic P-granules 5 autophagy tethering factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epg5provided by RGD
Official Full Name: ectopic P-granules 5 autophagy tethering factorprovided by RGD
Primary source: RGD:1306286
See related: EnsemblRapid:ENSRNOG00000052894 AllianceGenome:RGD:1306286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306286
Summary: Predicted to be involved in cellular response to dsDNA; endosome to lysosome transport; and nucleotide transport. Predicted to act upstream of with a positive effect on toll-like receptor 9 signaling pathway. Predicted to act upstream of or within several processes, including defense response to symbiont; homeostasis of number of retina cells; and host-mediated regulation of intestinal microbiota composition. Predicted to be located in lysosome and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Vici syndrome. Orthologous to human EPG5 (ectopic P-granules 5 autophagy tethering factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 127.2), Spleen (RPKM 124.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (73679106..73776694)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (71403990..71502079)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (74299965..74397115)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagosome maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dsDNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of retina cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within host-mediated regulation of intestinal microbiota composition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inclusion body assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of protein complex location	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mucosal immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nucleotide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein aggregate center assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to type III interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to unfolded protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ectopic P granules protein 5 homolog

Names: ectopic P-granules autophagy protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427613.1 → NP_001414542.1 ectopic P granules protein 5 homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A0G2JZ84, A6KMX2

Related

ENSRNOP00000070948.1, ENSRNOT00000078403.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

73679106..73776694

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277498.1 → XP_063133568.1 ectopic P granules protein 5 homolog isoform X1
XM_039097336.2 → XP_038953264.1 ectopic P granules protein 5 homolog isoform X2

UniProtKB/TrEMBL

A6KMX4
XM_039097337.2 → XP_038953265.1 ectopic P granules protein 5 homolog isoform X3

UniProtKB/TrEMBL

A6KMX4