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Sergef secretion regulating guanine nucleotide exchange factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 365243, updated on 2-Nov-2024

Summary

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Official Symbol
Sergefprovided by RGD
Official Full Name
secretion regulating guanine nucleotide exchange factorprovided by RGD
Primary source
RGD:1563497
See related
EnsemblRapid:ENSRNOG00000011488 AllianceGenome:RGD:1563497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563497
Summary
Predicted to be involved in negative regulation of protein secretion. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human SERGEF (secretion regulating guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 216.6), Kidney (RPKM 73.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sergef in Genome Data Viewer
Location:
1q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (106085950..106288815, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96949660..97152529, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102461327..102664978, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099806 Neighboring gene myogenic differentiation 1 Neighboring gene potassium voltage-gated channel subfamily C member 1 Neighboring gene uncharacterized LOC134485121 Neighboring gene uncharacterized LOC120099808 Neighboring gene tryptophan hydroxylase 1 Neighboring gene serum amyloid A-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. Sjölinder M, et al. FEBS Lett, 2002 Dec 4. PMID 12459492
  2. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness. Uhlmann J, et al. FEBS Lett, 1999 Oct 22. PMID 10571079
  3. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, et al. Front Genet, 2020. PMID 33381146, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
secretion-regulating guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400924.1 → NP_001387853.1  secretion-regulating guanine nucleotide exchange factor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JBC2, D3ZN16
    Related
    ENSRNOP00000015352.5, ENSRNOT00000015352.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    106085950..106288815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269165.1 → XP_063125235.1  secretion-regulating guanine nucleotide exchange factor isoform X5

  2. XM_039100958.1 → XP_038956886.1  secretion-regulating guanine nucleotide exchange factor isoform X3

    Conserved Domains (1) summary
    COG5184
    Location:17 → 304
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  3. XM_039100961.1 → XP_038956889.1  secretion-regulating guanine nucleotide exchange factor isoform X6

    Conserved Domains (1) summary
    COG5184
    Location:17 → 245
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  4. XM_006229229.4 → XP_006229291.1  secretion-regulating guanine nucleotide exchange factor isoform X7

    See identical proteins and their annotated locations for XP_006229291.1

    UniProtKB/TrEMBL
    A0A8I6AL11
    Conserved Domains (2) summary
    pfam00415
    Location:17 → 64
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:103 → 132
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  5. XM_039100959.1 → XP_038956887.1  secretion-regulating guanine nucleotide exchange factor isoform X4

    Related
    ENSRNOP00000093927.2, ENSRNOT00000097997.2
    Conserved Domains (1) summary
    COG5184
    Location:17 → 298
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  6. XM_039100957.1 → XP_038956885.1  secretion-regulating guanine nucleotide exchange factor isoform X1

    Conserved Domains (1) summary
    COG5184
    Location:17 → 325
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  7. XM_006229227.4 → XP_006229289.1  secretion-regulating guanine nucleotide exchange factor isoform X2

    See identical proteins and their annotated locations for XP_006229289.1

    UniProtKB/TrEMBL
    A0A8I6AL11
    Conserved Domains (2) summary
    pfam00415
    Location:17 → 64
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:103 → 132
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

  8. XM_063269181.1 → XP_063125251.1  secretion-regulating guanine nucleotide exchange factor isoform X8

  9. XM_063269178.1 → XP_063125248.1  secretion-regulating guanine nucleotide exchange factor isoform X8

  10. XM_039100966.2 → XP_038956894.1  secretion-regulating guanine nucleotide exchange factor isoform X9

    Conserved Domains (1) summary
    COG5184
    Location:17 → 279
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RNA

  1. XR_005499054.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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