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Cacul1 CDK2-associated, cullin domain 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365493, updated on 2-Nov-2024

Summary

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Official Symbol
Cacul1provided by RGD
Official Full Name
CDK2-associated, cullin domain 1provided by RGD
Primary source
RGD:1308127
See related
EnsemblRapid:ENSRNOG00000009954 AllianceGenome:RGD:1308127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308127
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Orthologous to human CACUL1 (CDK2 associated cullin domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 152.2), Lung (RPKM 150.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cacul1 in Genome Data Viewer
Location:
1q55
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (269652356..269712265, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (259666335..259726249, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (281814226..281874675, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 88 Neighboring gene prolactin releasing hormone receptor Neighboring gene small nuclear ribonucleoprotein 13, pseudogene 5 Neighboring gene uncharacterized LOC108349715 Neighboring gene uncharacterized LOC134485267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of CAC1 as a novel CDK2-associated cullin. Kong Y, et al. Cell Cycle, 2009 Nov 1. PMID 19829063
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CDK2-associated and cullin domain-containing protein 1
Names
uncharacterized protein C10orf46 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014248.2 → NP_001014270.1  CDK2-associated and cullin domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001014270.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q5XI53
    UniProtKB/TrEMBL
    A6JIA4
    Related
    ENSRNOP00000051311.2, ENSRNOT00000050617.5
    Conserved Domains (1) summary
    pfam00888
    Location:146 → 278
    Cullin; Cullin family

  2. NM_001416001.1 → NP_001402930.1  CDK2-associated and cullin domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K1Y0
    Related
    ENSRNOP00000072029.1, ENSRNOT00000084760.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    269652356..269712265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085812.2 → XP_038941740.1  CDK2-associated and cullin domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIA4
    Related
    ENSRNOP00000089369.1, ENSRNOT00000109460.2

  2. XM_039085806.2 → XP_038941734.1  CDK2-associated and cullin domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6JIA4
    Conserved Domains (1) summary
    pfam00888
    Location:145 → 269
    Cullin; Cullin family

  3. XM_063270019.1 → XP_063126089.1  CDK2-associated and cullin domain-containing protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI53.1 GenPept UniProtKB/Swiss-Prot:Q5XI53

Gene LinkOut

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