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Mblac2 metallo-beta-lactamase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365627, updated on 2-Nov-2024

Summary

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Official Symbol
Mblac2provided by RGD
Official Full Name
metallo-beta-lactamase domain containing 2provided by RGD
Primary source
RGD:1306703
See related
EnsemblRapid:ENSRNOG00000016252 AllianceGenome:RGD:1306703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306703
Summary
Predicted to enable beta-lactamase activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be located in endoplasmic reticulum membrane; mitochondrion; and plasma membrane. Orthologous to human MBLAC2 (metallo-beta-lactamase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 65.1), Liver (RPKM 44.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mblac2 in Genome Data Viewer
Location:
2q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (13721752..13764558)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (11986075..12028882)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (9578501..9621297)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17, pseudogene 7 Neighboring gene LysM domain containing 3 Neighboring gene RNA polymerase III subunit G Neighboring gene centrin 3 Neighboring gene uncharacterized LOC134485813

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-lactamase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-coenzyme A thioesterase MBLAC2
Names
metallo-beta-lactamase domain-containing protein 2
NP_001102404.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108934.1 → NP_001102404.1  acyl-coenzyme A thioesterase MBLAC2

    See identical proteins and their annotated locations for NP_001102404.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473955
    UniProtKB/TrEMBL
    A6I4J1, D4A249
    Related
    ENSRNOP00000021756.4, ENSRNOT00000021756.8
    Conserved Domains (1) summary
    cd07712
    Location:22 → 231
    MBLAC2-like_MBL-fold; uncharacterized human metallo-beta-lactamase domain-containing protein 2 and related proteins; MBL-fold metallo hydrolase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    13721752..13764558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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