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Nadk2 NAD kinase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 365699, updated on 28-Oct-2024

Summary

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Official Symbol
Nadk2provided by RGD
Official Full Name
NAD kinase 2, mitochondrialprovided by RGD
Primary source
RGD:1306809
See related
EnsemblRapid:ENSRNOG00000054157 AllianceGenome:RGD:1306809
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nadkd1; RGD1306809
Summary
Predicted to enable NAD+ kinase activity and protein homodimerization activity. Predicted to be involved in NAD metabolic process. Predicted to be active in mitochondrion. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Liver (RPKM 598.4), Adrenal (RPKM 340.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nadk2 in Genome Data Viewer
Location:
2q16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (59844854..59886989)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (58117674..58159815)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (58462588..58504735)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485718 Neighboring gene RAN binding protein 3-like Neighboring gene uncharacterized LOC120100736 Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene S-phase kinase associated protein 2 Neighboring gene LMBR1 domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase. Zhang R. J Cell Physiol, 2015 Aug. PMID 25641397
  2. Identification and characterization of a human mitochondrial NAD kinase. Ohashi K, et al. Nat Commun, 2012. PMID 23212377, Free PMC Article
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC125061

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in NAD metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in NADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NAD kinase 2, mitochondrial
Names
NAD kinase domain containing 1
NAD kinase domain-containing protein 1, mitochondrial
mitochondrial NAD kinase
NP_001037717.1
XP_006232076.1
XP_006232077.1
XP_006232078.1
XP_038958668.1
XP_038958669.1
XP_063138318.1
XP_063138319.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044252.2 → NP_001037717.1  NAD kinase 2, mitochondrial

    See identical proteins and their annotated locations for NP_001037717.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q1HCL7, Q3B8P3
    UniProtKB/TrEMBL
    A6KGJ0
    Related
    ENSRNOP00000074419.1, ENSRNOT00000083799.3
    Conserved Domains (1) summary
    cl01255
    Location:79 → 301
    DAGK_cat; Diacylglycerol kinase catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    59844854..59886989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232014.4 → XP_006232076.1  NAD kinase 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A096MKG5, A0A8I5ZN07
    Related
    ENSRNOP00000074867.2, ENSRNOT00000080618.3
    Conserved Domains (1) summary
    cl01255
    Location:82 → 326
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. XM_006232015.4 → XP_006232077.1  NAD kinase 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQT4, A6KGJ0
    Related
    ENSRNOP00000080674.1, ENSRNOT00000111710.2
    Conserved Domains (1) summary
    cl01255
    Location:82 → 304
    DAGK_cat; Diacylglycerol kinase catalytic domain

  3. XM_006232016.5 → XP_006232078.1  NAD kinase 2, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZN07
    Conserved Domains (1) summary
    cl01255
    Location:44 → 273
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. XM_063282248.1 → XP_063138318.1  NAD kinase 2, mitochondrial isoform X5

  5. XM_039102740.2 → XP_038958668.1  NAD kinase 2, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZN07
    Conserved Domains (1) summary
    cl01255
    Location:49 → 278
    DAGK_cat; Diacylglycerol kinase catalytic domain

  6. XM_039102741.2 → XP_038958669.1  NAD kinase 2, mitochondrial isoform X7

    Conserved Domains (1) summary
    cl01255
    Location:2 → 177
    DAGK_cat; Diacylglycerol kinase catalytic domain

  7. XM_063282249.1 → XP_063138319.1  NAD kinase 2, mitochondrial isoform X6

    Related
    ENSRNOP00000080309.2, ENSRNOT00000118441.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1HCL7.1 GenPept UniProtKB/Swiss-Prot:Q1HCL7

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