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Fstl5 follistatin-like 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365823, updated on 17-Aug-2024

Summary

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Official Symbol
Fstl5provided by RGD
Official Full Name
follistatin-like 5provided by RGD
Primary source
RGD:1306858
See related
EnsemblRapid:ENSRNOG00000047002 AllianceGenome:RGD:1306858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be located in extracellular region. Orthologous to human FSTL5 (follistatin like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 139.0) See more
Orthologs
human mouse all
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Genomic context

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Location:
2q32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (163156576..163825140)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (160857989..161526589)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (174542667..175234835)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene golgi integral membrane protein 4 Neighboring gene uncharacterized LOC102547227 Neighboring gene FtsJ RNA 2'-O-methyltransferase 3, pseudogene 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genetic association and characterization of FSTL5 in isolated clubfoot. Khanshour AM, et al. Hum Mol Genet, 2021 Jan 21. PMID 33105483, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic association and characterization of FSTL5 in isolated clubfoot.
    Title: Genetic association and characterization of FSTL5 in isolated clubfoot.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
follistatin-related protein 5
Names
ollistatin-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271195.1 → NP_001258124.1  follistatin-related protein 5 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A096MK67
    Related
    ENSRNOP00000068399.3, ENSRNOT00000076793.3
    Conserved Domains (6) summary
    cd05736
    Location:358 → 433
    Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
    smart00408
    Location:263 → 325
    IGc2; Immunoglobulin C-2 Type
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam07679
    Location:341 → 430
    I-set; Immunoglobulin I-set domain
    pfam13499
    Location:182 → 242
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:180 → 243
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    163156576..163825140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102752.2 → XP_038958680.1  follistatin-related protein 5 isoform X5

    Conserved Domains (5) summary
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:182 → 243
    EF-hand_7; EF-hand domain pair
    pfam13927
    Location:256 → 323
    Ig_3; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand B [structural motif]
    cd05736
    Location:341 → 433
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

  2. XM_039102749.2 → XP_038958677.1  follistatin-related protein 5 isoform X3

    Related
    ENSRNOP00000106821.1, ENSRNOT00000166427.1
    Conserved Domains (5) summary
    cd00104
    Location:93 → 133
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:182 → 243
    EF-hand_7; EF-hand domain pair
    pfam13927
    Location:256 → 323
    Ig_3; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand B [structural motif]
    cd05736
    Location:341 → 433
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

  3. XM_063282254.1 → XP_063138324.1  follistatin-related protein 5 isoform X6

  4. XM_017590994.3 → XP_017446483.1  follistatin-related protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A096MK67

  5. XM_039102750.2 → XP_038958678.1  follistatin-related protein 5 isoform X4

    Conserved Domains (5) summary
    cd00104
    Location:92 → 132
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam13499
    Location:181 → 242
    EF-hand_7; EF-hand domain pair
    pfam13927
    Location:255 → 322
    Ig_3; Immunoglobulin domain
    cd00096
    Location:265 → 269
    Ig; Ig strand B [structural motif]
    cd05736
    Location:340 → 432
    IgI_2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

  6. XM_063282253.1 → XP_063138323.1  follistatin-related protein 5 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108946.1: Suppressed sequence

    Description
    NM_001108946.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: FSTL5 (GeneID:56884).
Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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