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Clk2 CDC-like kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365842, updated on 18-Sep-2024

Summary

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Official Symbol
Clk2provided by RGD
Official Full Name
CDC-like kinase 2provided by RGD
Primary source
RGD:1359711
See related
EnsemblRapid:ENSRNOG00000077782 AllianceGenome:RGD:1359711
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including negative regulation of gluconeogenesis; regulation of RNA splicing; and response to ionizing radiation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation; protein autophosphorylation; and response to retinoic acid. Predicted to be located in nuclear body. Orthologous to human CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 115.0), Kidney (RPKM 99.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clk2 in Genome Data Viewer
Location:
2q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176868423..176880412)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174570614..174582645)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188476789..188488809)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 909 Neighboring gene farnesyl diphosphate synthase Neighboring gene pyruvate kinase L/R Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Neighboring gene microRNA 3541 Neighboring gene secretory carrier membrane protein 3 Neighboring gene endosomal transmembrane epsin interactor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Rodgers JT, et al. Cell Metab, 2010 Jan. PMID 20074525, Free PMC Article
  2. The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation. Nayler O, et al. J Biol Chem, 1998 Dec 18. PMID 9852100
  3. Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation. Nam SY, et al. J Biol Chem, 2010 Oct 8. PMID 20682768, Free PMC Article
  4. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan PI, et al. Exp Cell Res, 1998 Jun 15. PMID 9637771
  5. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Kulkarni P, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289210, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to retinoic acid ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein kinase CLK2
NP_001014276.1
XP_008759408.1
XP_008759409.1
XP_008759411.1
XP_008759412.1
XP_008759413.1
XP_008759414.1
XP_038958690.1
XP_063138326.1
XP_063138327.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014254.1 → NP_001014276.1  dual specificity protein kinase CLK2

    See identical proteins and their annotated locations for NP_001014276.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083788
    UniProtKB/TrEMBL
    A0A0G2K5Q8, F1LNQ0, Q5XI98
    Conserved Domains (1) summary
    cd14215
    Location:150 → 479
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176868423..176880412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761186.4 → XP_008759408.1  dual specificity protein kinase CLK2 isoform X1

    See identical proteins and their annotated locations for XP_008759408.1

    Conserved Domains (2) summary
    smart00220
    Location:203 → 519
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:190 → 519
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  2. XM_008761187.4 → XP_008759409.1  dual specificity protein kinase CLK2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:202 → 518
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:189 → 518
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  3. XM_039102762.2 → XP_038958690.1  dual specificity protein kinase CLK2 isoform X3

    Conserved Domains (1) summary
    cd14215
    Location:183 → 512
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  4. XM_008761189.4 → XP_008759411.1  dual specificity protein kinase CLK2 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:195 → 511
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:182 → 511
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  5. XM_008761190.4 → XP_008759412.1  dual specificity protein kinase CLK2 isoform X5

    Related
    ENSRNOP00000073519.3, ENSRNOT00000085817.3
    Conserved Domains (2) summary
    smart00220
    Location:195 → 511
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:182 → 511
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  6. XM_008761191.4 → XP_008759413.1  dual specificity protein kinase CLK2 isoform X6

    Conserved Domains (2) summary
    smart00220
    Location:194 → 510
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:181 → 510
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  7. XM_008761192.4 → XP_008759414.1  dual specificity protein kinase CLK2 isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:170 → 486
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14215
    Location:157 → 486
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

  8. XM_063282256.1 → XP_063138326.1  dual specificity protein kinase CLK2 isoform X8

    UniProtKB/TrEMBL
    A6J6C3

  9. XM_063282257.1 → XP_063138327.1  dual specificity protein kinase CLK2 isoform X9

    Related
    ENSRNOP00000027793.7, ENSRNOT00000027793.8

RNA

  1. XR_010063630.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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