U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tlcd4 TLC domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365924, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Tlcd4provided by RGD
Official Full Name
TLC domain containing 4provided by RGD
Primary source
RGD:1563041
See related
EnsemblRapid:ENSRNOG00000025160 AllianceGenome:RGD:1563041
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem56; RGD1563041
Summary
Predicted to be involved in lipid homeostasis. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to several human genes including TLCD4 (TLC domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 162.6), Muscle (RPKM 162.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2q42
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (211969612..212044883, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (209284873..209360156, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (224768034..224843198, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RWD domain containing 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene ALG14, UDP-N-acetylglucosaminyltransferase subunit Neighboring gene ribosomal protein S19, pseudogene 5 Neighboring gene uncharacterized LOC120100935

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TLC domain-containing protein 4
Names
transmembrane protein 56

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135879.1 → NP_001129351.1  TLC domain-containing protein 4

    See identical proteins and their annotated locations for NP_001129351.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    211969612..212044883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233252.5 → XP_006233314.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233314.1

    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  2. XM_039102803.2 → XP_038958731.1  TLC domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  3. XM_006233251.5 → XP_006233313.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233313.1

    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  4. XM_039102801.2 → XP_038958729.1  TLC domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  5. XM_063282296.1 → XP_063138366.1  TLC domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D4AAE5

  6. XM_006233246.5 → XP_006233308.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233308.1

    UniProtKB/TrEMBL
    D4AAE5
    Related
    ENSRNOP00000033667.3, ENSRNOT00000032324.6
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  7. XM_006233244.5 → XP_006233306.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233306.1

    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  8. XM_006233253.5 → XP_006233315.1  TLC domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233315.1

    UniProtKB/TrEMBL
    D4AAE5
    Conserved Domains (1) summary
    smart00724
    Location:45 → 246
    TLC; TRAM, LAG1 and CLN8 homology domains

  9. XM_063282294.1 → XP_063138364.1  TLC domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D4AAE5

  10. XM_063282295.1 → XP_063138365.1  TLC domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D4AAE5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools