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Fastkd5 FAST kinase domains 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366192, updated on 2-Nov-2024

Summary

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Symbol
Fastkd5provided by RGD
Full Name
FAST kinase domains 5provided by RGD
Primary source
RGD:1563839
See related
EnsemblRapid:ENSRNOG00000053270 AllianceGenome:RGD:1563839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563839; Fastkd5-ps1; AABR07053741.1
Summary
Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial RNA processing. Predicted to be located in mitochondrial nucleoid and ribonucleoprotein granule. Orthologous to human FASTKD5 (FAST kinase domains 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 80.7), Thymus (RPKM 76.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fastkd5 in Genome Data Viewer
Location:
3q36
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138283315..138300803, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117830219..117847707, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123154263..123170615, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene oxytocin/neurophysin I prepropeptide Neighboring gene arginine vasopressin Neighboring gene U-box domain containing 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Antonicka H, et al. Cell Rep, 2015 Feb 17. PMID 25683715
  2. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FAST kinase domain-containing protein 5, mitochondrial
Names
FAST kinase domains 5, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399367.1 → NP_001386296.1  FAST kinase domain-containing protein 5, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AAM0
    Conserved Domains (3) summary
    smart00952
    Location:699 → 758
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:431 → 500
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:512 → 601
    FAST_2; FAST kinase-like protein, subdomain 2

  2. NM_001399368.1 → NP_001386297.1  FAST kinase domain-containing protein 5, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AAM0
    Related
    ENSRNOP00000089567.1, ENSRNOT00000117848.2
    Conserved Domains (3) summary
    smart00952
    Location:699 → 758
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:431 → 500
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:512 → 601
    FAST_2; FAST kinase-like protein, subdomain 2

  3. NM_001399369.1 → NP_001386298.1  FAST kinase domain-containing protein 5, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AAM0
    Conserved Domains (3) summary
    smart00952
    Location:699 → 758
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:431 → 500
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:512 → 601
    FAST_2; FAST kinase-like protein, subdomain 2

  4. NM_001399370.1 → NP_001386299.1  FAST kinase domain-containing protein 5, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AAM0
    Related
    ENSRNOP00000100700.1, ENSRNOT00000170345.1
    Conserved Domains (3) summary
    smart00952
    Location:699 → 758
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:431 → 500
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:512 → 601
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138283315..138300803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials