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Rab22a RAB22A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 366265, updated on 2-Nov-2024

Summary

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Official Symbol
Rab22aprovided by RGD
Official Full Name
RAB22A, member RAS oncogene familyprovided by RGD
Primary source
RGD:1311959
See related
EnsemblRapid:ENSRNOG00000005762 AllianceGenome:RGD:1311959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including endosome organization; intracellular protein transport; and regulation of vesicle size. Predicted to be located in actin cytoskeleton; phagocytic vesicle; and plasma membrane. Predicted to be active in early endosome. Orthologous to human RAB22A (RAB22A, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 36.2), Kidney (RPKM 34.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rab22a in Genome Data Viewer
Location:
3q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (182877746..182924400)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (162459727..162506129)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (171743884..171790558)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 9 Neighboring gene uncharacterized LOC134486505 Neighboring gene VAMP associated protein B and C Neighboring gene APC down-regulated 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human liver cell trafficking mutants: characterization and whole exome sequencing. Yuan F, et al. PLoS One, 2014. PMID 24466322, Free PMC Article
  2. The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. Kauppi M, et al. J Cell Sci, 2002 Mar 1. PMID 11870209
  3. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article
  4. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Eathiraj S, et al. Nature, 2005 Jul 21. PMID 16034420, Free PMC Article
  5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Seto S, et al. Traffic, 2011 Apr. PMID 21255211

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of vesicle size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-22A
NP_001385874.1
XP_063140363.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398945.1 → NP_001385874.1  ras-related protein Rab-22A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A9K3Y893, B0BN19, D4A9H0
    Related
    ENSRNOP00000106765.1, ENSRNOT00000129296.1
    Conserved Domains (1) summary
    cd01860
    Location:5 → 167
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    182877746..182924400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284293.1 → XP_063140363.1  ras-related protein Rab-22A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AES5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108966.1: Suppressed sequence

    Description
    NM_001108966.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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