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Polr3k RNA polymerase III subunit K [ Rattus norvegicus (Norway rat) ]

Gene ID: 366277, updated on 2-Nov-2024

Summary

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Official Symbol
Polr3kprovided by RGD
Official Full Name
RNA polymerase III subunit Kprovided by RGD
Primary source
RGD:1587294
See related
EnsemblRapid:ENSRNOG00000086796 AllianceGenome:RGD:1587294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Orthologous to human POLR3K (RNA polymerase III subunit K). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 269.4), Adrenal (RPKM 207.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Polr3k in Genome Data Viewer
Location:
3q43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189360349..189364546)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168982846..168987043)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177374812..177379009)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myelin transcription factor 1 Neighboring gene uncharacterized LOC134486518 Neighboring gene uncharacterized LOC120101836 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene zinc finger protein 431-like Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a uterine luminal fluid protein ULF-250 using N-terminal microsequencing and RT-PCR identifies a novel estrogen-regulated gene in the rat uterus. Kumar G P, et al. FEBS Lett, 1996 Dec 9. PMID 8980114
  2. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
  3. Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits. Hu P, et al. Mol Cell Biol, 2002 Nov. PMID 12391170, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109430

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in termination of RNA polymerase III transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC10
Names
estrous-specific protein, 250 kDa
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
polymerase (RNA) III subunit K
NP_001014281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014259.1 → NP_001014281.1  DNA-directed RNA polymerase III subunit RPC10

    See identical proteins and their annotated locations for NP_001014281.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089990
    UniProtKB/TrEMBL
    A0A8I5ZSQ8, Q5FVH1
    Related
    ENSRNOP00000112308.1, ENSRNOT00000152660.1
    Conserved Domains (2) summary
    COG1594
    Location:1 → 108
    RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]
    cd10509
    Location:61 → 108
    Zn-ribbon_RPC11; C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    189360349..189364546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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