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Uqcrh ubiquinol-cytochrome c reductase hinge protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 366448, updated on 2-Nov-2024

Summary

Official Symbol
Uqcrhprovided by RGD
Official Full Name
ubiquinol-cytochrome c reductase hinge proteinprovided by RGD
Primary source
RGD:1305987
See related
AllianceGenome:RGD:1305987
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRH (ubiquinol-cytochrome c reductase hinge protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 4282.8), Muscle (RPKM 2924.9) and 9 other tissues See more
Orthologs
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Genomic context

See Uqcrh in Genome Data Viewer
Location:
5q35
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134782687..134790882, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129545978..129554173, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134919040..134927235, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene fatty acid amide hydrolase Neighboring gene NOP2/Sun RNA methyltransferase 4 Neighboring gene uncharacterized LOC134486970 Neighboring gene leucine rich repeat containing 41 Neighboring gene RAD54 like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC109658

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquinol-cytochrome-c reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquinol-cytochrome-c reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of respiratory chain complex III IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 6, mitochondrial
Names
complex III subunit 6
complex III subunit VIII
cytochrome c1 non-heme 11 kDa protein
mitochondrial hinge protein
ubiquinol-cytochrome c reductase complex 11 kDa protein
NP_001009480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009480.1NP_001009480.1  cytochrome b-c1 complex subunit 6, mitochondrial

    See identical proteins and their annotated locations for NP_001009480.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086954
    UniProtKB/Swiss-Prot
    Q5M9I5
    UniProtKB/TrEMBL
    A0A8L2Q828, A6JZ59
    Conserved Domains (1) summary
    pfam02320
    Location:2688
    UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    134782687..134790882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)