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Pigv phosphatidylinositol glycan anchor biosynthesis, class V [ Rattus norvegicus (Norway rat) ]

Gene ID: 366478, updated on 2-Nov-2024

Summary

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Official Symbol
Pigvprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Vprovided by RGD
Primary source
RGD:1309526
See related
EnsemblRapid:ENSRNOG00000000121 AllianceGenome:RGD:1309526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309526
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be part of mannosyltransferase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 1. Orthologous to human PIGV (phosphatidylinositol glycan anchor biosynthesis class V). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 27.6), Spleen (RPKM 25.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pigv in Genome Data Viewer
Location:
5q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151173486..151185748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145889642..145901533, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151886132..151899024, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 25 member 33, pseudogene 1 Neighboring gene AT-rich interaction domain 1A Neighboring gene NOP10 ribonucleoprotein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Krawitz PM, et al. Nat Genet, 2010 Oct. PMID 20802478
  2. Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly. Fabre AL, et al. FEBS J, 2005 Mar. PMID 15720390
  3. PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. Kang JY, et al. J Biol Chem, 2005 Mar 11. PMID 15623507
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycolipid mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mannosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GPI mannosyltransferase 2
Names
GPI mannosyltransferase II
GPI-MT-II
PIG-V
phosphatidylinositol glycan, class V
phosphatidylinositol-glycan biosynthesis class V protein
NP_001010966.1
XP_006239117.1
XP_017449033.1
XP_017449034.1
XP_017449035.1
XP_038966407.1
XP_038966408.1
XP_038966410.1
XP_038966411.1
XP_038966412.1
XP_038966413.1
XP_063144193.1
XP_063144194.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010966.1 → NP_001010966.1  GPI mannosyltransferase 2

    See identical proteins and their annotated locations for NP_001010966.1

    Status: PROVISIONAL

    Source sequence(s)
    AB196341
    UniProtKB/Swiss-Prot
    Q5KR61
    UniProtKB/TrEMBL
    A0A8L2R8F0
    Related
    ENSRNOP00000000133.4, ENSRNOT00000000133.6
    Conserved Domains (1) summary
    pfam04188
    Location:9 → 492
    Mannosyl_trans2; Mannosyltransferase (PIG-V)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151173486..151185748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110485.2 → XP_038966413.1  GPI mannosyltransferase 2 isoform X4

    Related
    ENSRNOP00000073811.3, ENSRNOT00000081841.3
    Conserved Domains (1) summary
    cl21590
    Location:25 → 118
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. XM_017593545.3 → XP_017449034.1  GPI mannosyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5KR61
    UniProtKB/TrEMBL
    A0A8L2R8F0
    Conserved Domains (1) summary
    pfam04188
    Location:9 → 492
    Mannosyl_trans2; Mannosyltransferase (PIG-V)

  3. XM_063288124.1 → XP_063144194.1  GPI mannosyltransferase 2 isoform X4

  4. XM_039110480.2 → XP_038966408.1  GPI mannosyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5KR61
    UniProtKB/TrEMBL
    A0A8L2R8F0
    Conserved Domains (1) summary
    pfam04188
    Location:9 → 492
    Mannosyl_trans2; Mannosyltransferase (PIG-V)

  5. XM_017593546.3 → XP_017449035.1  GPI mannosyltransferase 2 isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:25 → 118
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  6. XM_039110482.2 → XP_038966410.1  GPI mannosyltransferase 2 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:81 → 287
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  7. XM_006239055.5 → XP_006239117.1  GPI mannosyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006239117.1

    UniProtKB/Swiss-Prot
    Q5KR61
    UniProtKB/TrEMBL
    A0A8L2R8F0
    Conserved Domains (1) summary
    pfam04188
    Location:9 → 492
    Mannosyl_trans2; Mannosyltransferase (PIG-V)

  8. XM_039110483.2 → XP_038966411.1  GPI mannosyltransferase 2 isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:25 → 118
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  9. XM_017593544.3 → XP_017449033.1  GPI mannosyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5KR61
    UniProtKB/TrEMBL
    A0A8L2R8F0
    Conserved Domains (1) summary
    pfam04188
    Location:9 → 492
    Mannosyl_trans2; Mannosyltransferase (PIG-V)

  10. XM_039110484.2 → XP_038966412.1  GPI mannosyltransferase 2 isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:25 → 118
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  11. XM_039110479.2 → XP_038966407.1  GPI mannosyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5KR61
    UniProtKB/TrEMBL
    A0A8L2R8F0
    Conserved Domains (1) summary
    pfam04188
    Location:9 → 492
    Mannosyl_trans2; Mannosyltransferase (PIG-V)

  12. XM_063288123.1 → XP_063144193.1  GPI mannosyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    A6ISY4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5KR61.1 GenPept UniProtKB/Swiss-Prot:Q5KR61

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