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Dtd2 D-aminoacyl-tRNA deacylase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366619, updated on 17-Aug-2024

Summary

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Official Symbol
Dtd2provided by RGD
Official Full Name
D-aminoacyl-tRNA deacylase 2provided by RGD
Primary source
RGD:1309138
See related
EnsemblRapid:ENSRNOG00000006727 AllianceGenome:RGD:1309138
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309138
Summary
Predicted to enable Ala-tRNA(Thr) hydrolase activity and D-tyrosyl-tRNA(Tyr) deacylase activity. Predicted to be involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. Orthologous to human DTD2 (D-aminoacyl-tRNA deacylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 107.2), Kidney (RPKM 82.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtd2 in Genome Data Viewer
Location:
6q23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75185496..75191774, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69450146..69456430, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72781229..72786835, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479181 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene HEAT repeat containing 5A Neighboring gene uncharacterized LOC134479124 Neighboring gene G protein-coupled receptor 33, pseudogene 1 Neighboring gene tensin-2 pseudogene Neighboring gene NUBP iron-sulfur cluster assembly factor like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia. Kuncha SK, et al. Nat Commun, 2018 Feb 6. PMID 29410408, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Ala-tRNA(Thr) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-tyrosyl-tRNA(Tyr) deacylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aminoacyl-tRNA metabolism involved in translational fidelity ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
D-aminoacyl-tRNA deacylase 2
Names
D-tyrosyl-tRNA deacylase 2 (putative)
probable D-tyrosyl-tRNA(Tyr) deacylase 2
NP_001102451.1
XP_038968558.1
XP_038968559.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108981.1 → NP_001102451.1  D-aminoacyl-tRNA deacylase 2

    See identical proteins and their annotated locations for NP_001102451.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/TrEMBL
    A6HBI1, B0K034, F7FIM5
    Related
    ENSRNOP00000009020.3, ENSRNOT00000009020.5
    Conserved Domains (1) summary
    pfam02580
    Location:12 → 167
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    75185496..75191774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112630.2 → XP_038968558.1  D-aminoacyl-tRNA deacylase 2 isoform X1

    Conserved Domains (1) summary
    pfam02580
    Location:1 → 108
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

  2. XM_039112631.2 → XP_038968559.1  D-aminoacyl-tRNA deacylase 2 isoform X1

    Conserved Domains (1) summary
    pfam02580
    Location:1 → 108
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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