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CG7544 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36680, updated on 2-Nov-2024

Summary

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Official Symbol
CG7544provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033994
Locus tag
Dmel_CG7544
See related
AllianceGenome:FB:FBgn0033994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7544; METTL16
Summary
Predicted to enable 23S rRNA (adenine(1618)-N(6))-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG7544 in Genome Data Viewer
Location:
51E2-51E2; 2-74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15147860..15149709)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11035365..11037214)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit K Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43831 Neighboring gene igloo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction of an alpaca immune antibody library for the selection of nanobodies against Drosophila melanogaster proteins. Qiu J, et al. Front Bioeng Biotechnol, 2023. PMID 37362207, Free PMC Article
  2. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
  3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
  4. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
  5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA base methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7544-PA
CG7544-PB
NP_001163156.1
NP_611015.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15147860..15149709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169685.2 → NP_001163156.1  uncharacterized protein Dmel_CG7544, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K3B9
    UniProtKB/TrEMBL
    E1JH71
    Conserved Domains (1) summary
    cl17173
    Location:45 → 295
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_137171.4 → NP_611015.1  uncharacterized protein Dmel_CG7544, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611015.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K3B9
    UniProtKB/TrEMBL
    E1JH71
    Related
    FBpp0086548
    Conserved Domains (1) summary
    cl17173
    Location:45 → 295
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JH71 E1JH71
Q7K3B9.1 Q7K3B9

Gene LinkOut

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