Gcat glycine C-acetyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gcatprovided by RGD
Official Full Name: glycine C-acetyltransferaseprovided by RGD
Primary source: RGD:1307291
See related: EnsemblRapid:ENSRNOG00000055408 AllianceGenome:RGD:1307291
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glycine C-acetyltransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in biosynthetic process and threonine catabolic process. Predicted to be located in nuclear speck. Predicted to be active in mitochondrion. Orthologous to human GCAT (glycine C-acetyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 144.8), Kidney (RPKM 134.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112475572..112481920)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110595126..110601474)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120263068..120269365)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128164 (e-PCR)
- UniSTS:211472

AW531813 (e-PCR)
- UniSTS:260538

BI278594 (e-PCR)
- UniSTS:244419

U18295 (e-PCR)
- UniSTS:186317

D7Wox47 (e-PCR)
- UniSTS:518888

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycine C-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in threonine catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

Names: glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

NP_001019448.1

EC 2.3.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024277.1 → NP_001019448.1 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

See identical proteins and their annotated locations for NP_001019448.1

Status: PROVISIONAL

Source sequence(s)

BC092591

UniProtKB/TrEMBL

A0A0G2K2Q2, A6HSN9, Q562C3

Related

ENSRNOP00000072331.2, ENSRNOT00000078383.3

Conserved Domains (2) summary

COG0156
Location:28 → 409

BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

cl18945
Location:24 → 415

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...