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Ap1m2 adaptor related protein complex 1 subunit mu 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367038, updated on 17-Aug-2024

Summary

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Official Symbol
Ap1m2provided by RGD
Official Full Name
adaptor related protein complex 1 subunit mu 2provided by RGD
Primary source
RGD:1561490
See related
EnsemblRapid:ENSRNOG00000043093 AllianceGenome:RGD:1561490
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561490
Summary
Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Orthologous to human AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 108.4), Lung (RPKM 75.7) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap1m2 in Genome Data Viewer
Location:
8q13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28114748..28132767, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19838579..19856560, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22318941..22336827, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene solute carrier family 44 member 2 Neighboring gene interleukin enhancer binding factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium. Efendiev R, et al. Circ Res, 2004 Nov 26. PMID 15528469
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase activity, adaptin-2 mu2-subunit hyperphosphorylation, and impaired Na+,K+-ATPase endocytosis.
    Title: Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-1 complex subunit mu-2
Names
AP-mu chain family member mu1B
Golgi adaptor HA1/AP1 adaptin mu-2 subunit
adaptor protein complex AP-1 subunit mu-2
adaptor-related protein complex 1, mu 2 subunit
clathrin assembly protein complex 1 mu-2 medium chain 2
mu-adaptin 2
mu1B-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108996.4 → NP_001102466.1  AP-1 complex subunit mu-2

    See identical proteins and their annotated locations for NP_001102466.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    D3ZRP6
    UniProtKB/TrEMBL
    B2RZA4
    Related
    ENSRNOP00000093034.1, ENSRNOT00000106767.2
    Conserved Domains (2) summary
    cd14835
    Location:4 → 142
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    cl10970
    Location:154 → 421
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28114748..28132767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081849.2 → XP_038937777.1  AP-1 complex subunit mu-2 isoform X1

    UniProtKB/Swiss-Prot
    D3ZRP6
    UniProtKB/TrEMBL
    A0A8Q5ZZY5
    Related
    ENSRNOP00000063098.3, ENSRNOT00000066340.5
    Conserved Domains (2) summary
    cd14835
    Location:4 → 142
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    cl10970
    Location:154 → 423
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZRP6.2 GenPept UniProtKB/Swiss-Prot:D3ZRP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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