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Dock6 dedicator of cytokinesis 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367039, updated on 10-Oct-2024

Summary

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Official Symbol
Dock6provided by RGD
Official Full Name
dedicator of cytokinesis 6provided by RGD
Primary source
RGD:1306517
See related
EnsemblRapid:ENSRNOG00000010652 AllianceGenome:RGD:1306517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 80.9), Kidney (RPKM 47.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dock6 in Genome Data Viewer
Location:
8q13
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28618523..28670741, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20342430..20394660, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22822412..22874670, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene angiopoietin-like 8 Neighboring gene uncharacterized LOC120094090 Neighboring gene RAB3D, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Chi HC, et al. Oncogene, 2020 Sep. PMID 32753649
  2. Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis. Zhang ZY, et al. Arch Oral Biol, 2022 Jan. PMID 34742001
  3. DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies. Sukalo M, et al. Hum Mutat, 2015 Jun. PMID 25824905
  4. miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis. Li X, et al. J Exp Clin Cancer Res, 2018 Mar 27. PMID 29587866, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dedicator of cytokinesis protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394344.1 → NP_001381273.1  dedicator of cytokinesis protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6ANH8, D3ZY19
    Related
    ENSRNOP00000063161.2, ENSRNOT00000064551.4
    Conserved Domains (3) summary
    cd08696
    Location:547 → 724
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1658 → 2080
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  2. NM_001413911.1 → NP_001400840.1  dedicator of cytokinesis protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2KAH4
    Related
    ENSRNOP00000075398.2, ENSRNOT00000090424.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28618523..28670741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081852.1 → XP_038937780.1  dedicator of cytokinesis protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ANH8
    Related
    ENSRNOP00000079526.2, ENSRNOT00000106365.2
    Conserved Domains (3) summary
    cd08696
    Location:547 → 724
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1633 → 2055
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  2. XM_039081851.1 → XP_038937779.1  dedicator of cytokinesis protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ANH8
    Conserved Domains (3) summary
    cd08696
    Location:547 → 724
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1637 → 2059
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  3. XM_039081850.1 → XP_038937778.1  dedicator of cytokinesis protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ANH8
    Conserved Domains (3) summary
    cd08696
    Location:547 → 724
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1668 → 2090
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  4. XM_063265870.1 → XP_063121940.1  dedicator of cytokinesis protein 6 isoform X5

    Related
    ENSRNOP00000111360.1, ENSRNOT00000162151.1

  5. XM_063265869.1 → XP_063121939.1  dedicator of cytokinesis protein 6 isoform X4

  6. XM_039081854.2 → XP_038937782.1  dedicator of cytokinesis protein 6 isoform X6

    UniProtKB/TrEMBL
    A6JNU8
    Conserved Domains (3) summary
    cd08696
    Location:547 → 724
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)
    cl06123
    Location:1629 → 1772
    DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

  7. XM_039081855.2 → XP_038937783.1  dedicator of cytokinesis protein 6 isoform X7

    Conserved Domains (2) summary
    cd08696
    Location:547 → 724
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:48 → 157
    DUF3398; Domain of unknown function (DUF3398)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108997.1: Suppressed sequence

    Description
    NM_001108997.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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