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Trappc4 trafficking protein particle complex subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367073, updated on 28-Oct-2024

Summary

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Official Symbol
Trappc4provided by RGD
Official Full Name
trafficking protein particle complex subunit 4provided by RGD
Primary source
RGD:1302991
See related
EnsemblRapid:ENSRNOG00000011904 AllianceGenome:RGD:1302991
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sbdn
Summary
Predicted to be involved in autophagy; dendrite development; and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in Golgi stack; dendrite; and synaptic vesicle. Predicted to be part of TRAPP complex. Predicted to be active in postsynaptic density membrane and presynaptic active zone. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 90.9), Brain (RPKM 86.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trappc4 in Genome Data Viewer
Location:
8q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53626382..53630042, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44729458..44733285, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48723755..48727182, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene hypoxia up-regulated 1 Neighboring gene solute carrier family 37 member 4 Neighboring gene ribosomal protein s25 Neighboring gene centrosomal AT-AC splicing factor Neighboring gene methyltransferase like 9, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability. Van Bergen NJ, et al. Brain, 2020 Jan 1. PMID 31794024, Free PMC Article
  2. Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines. Ethell IM, et al. J Cell Biol, 2000 Oct 2. PMID 11018053, Free PMC Article
  3. mBET3 is required for the organization of the TRAPP complexes. Menon S, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17027922
  4. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Scrivens PJ, et al. Mol Biol Cell, 2011 Jun 15. PMID 21525244, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
  
involved_in dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex ISO
Inferred from Sequence Orthology
more info
  
part_of TRAPP complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trafficking protein particle complex subunit 4
Names
synbindin
trafficking protein particle complex 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003708.1 → NP_001003708.1  trafficking protein particle complex subunit 4

    See identical proteins and their annotated locations for NP_001003708.1

    Status: PROVISIONAL

    Source sequence(s)
    AY373378
    UniProtKB/Swiss-Prot
    Q4G098, Q69BT7
    UniProtKB/TrEMBL
    A0A8I6A204
    Related
    ENSRNOP00000016145.4, ENSRNOT00000016145.8
    Conserved Domains (1) summary
    pfam04099
    Location:3 → 209
    Sybindin; Sybindin-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53626382..53630042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081858.2 → XP_038937786.1  trafficking protein particle complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A204, A0A8I6GKF4, A6J3Y3
    Related
    ENSRNOP00000093760.1, ENSRNOT00000112974.2
    Conserved Domains (1) summary
    cd14856
    Location:4 → 193
    TRAPPC4_synbindin; Trafficking protein particle complex subunit 4

  2. XM_039081859.2 → XP_038937787.1  trafficking protein particle complex subunit 4 isoform X2

    Conserved Domains (1) summary
    cl38905
    Location:45 → 99
    longin-like; Longin-like domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69BT7.1 GenPept UniProtKB/Swiss-Prot:Q69BT7

Gene LinkOut

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