Sln sarcolipin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slnprovided by RGD
Official Full Name: sarcolipinprovided by RGD
Primary source: RGD:1305224
See related: EnsemblRapid:ENSRNOG00000009047 AllianceGenome:RGD:1305224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme regulator activity. Predicted to be involved in several processes, including negative regulation of ATPase-coupled calcium transmembrane transporter activity; positive regulation of cold-induced thermogenesis; and sarcoplasmic reticulum calcium ion transport. Predicted to be located in sarcoplasmic reticulum membrane. Orthologous to human SLN (sarcolipin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 1450.2), Lung (RPKM 361.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (63117577..63144290)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (54221389..54248110)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (58431407..58435654)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we generated right-sided pressure-overload models by monocrotaline administration in Wistar rats. Monocrotaline administration significantly decreased expression of sarcolipin, SERCA2a, & phospholamban mRNAs in right atrium than those in left atrium.
Title: Mechanical stress-dependent transcriptional regulation of sarcolipin gene in the rodent atrium.
The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression.
Title: Post-transcriptional downregulation of sarcolipin mRNA by triiodothyronine in the atrial myocardium.
The expression of SLN and PLB mRNA and protein relative to SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig.
Title: Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127388 (e-PCR)
- UniSTS:210698

RH140873 (e-PCR)
- UniSTS:210698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATPase-coupled calcium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of ATPase-coupled calcium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info
involved_in regulation of relaxation of muscle	ISS Inferred from Sequence or Structural Similarity more info
involved_in sarcoplasmic reticulum calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sarcoplasmic reticulum calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sarcolipin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013247.1 → NP_001013265.1 sarcolipin

See identical proteins and their annotated locations for NP_001013265.1

Status: PROVISIONAL

Source sequence(s)

AY456000

UniProtKB/Swiss-Prot

Q6SLE7

Related

ENSRNOP00000011970.3, ENSRNOT00000011974.6

Conserved Domains (1) summary

cd20253
Location:2 → 31

Sarcolipin; Sarcolipin bioactive peptide and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

63117577..63144290

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081872.2 → XP_038937800.1 sarcolipin isoform X1

UniProtKB/Swiss-Prot

Q6SLE7

Conserved Domains (1) summary

cd20253
Location:2 → 31

Sarcolipin; Sarcolipin bioactive peptide and similar proteins
XM_039081871.2 → XP_038937799.1 sarcolipin isoform X1

UniProtKB/Swiss-Prot

Q6SLE7

Conserved Domains (1) summary

cd20253
Location:2 → 31

Sarcolipin; Sarcolipin bioactive peptide and similar proteins