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Lrrc1 leucine rich repeat containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367113, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc1provided by RGD
Official Full Name
leucine rich repeat containing 1provided by RGD
Primary source
RGD:1549773
See related
EnsemblRapid:ENSRNOG00000005970 AllianceGenome:RGD:1549773
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LRRC1 (leucine rich repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 167.8), Kidney (RPKM 113.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrc1 in Genome Data Viewer
Location:
8q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (87120281..87289748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (78239897..78407347, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (84721621..84835074, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene tubulointerstitial nephritis antigen Neighboring gene muscular LMNA-interacting protein Neighboring gene uncharacterized LOC120094211 Neighboring gene uncharacterized LOC108351748

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3. Wang Y, et al. Int J Mol Sci, 2024 Feb 27. PMID 38473980, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
    Title: The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014268.1 → NP_001014290.1  leucine-rich repeat-containing protein 1

    See identical proteins and their annotated locations for NP_001014290.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079423
    UniProtKB/TrEMBL
    A6I1G1, Q6AXP5
    Related
    ENSRNOP00000007867.5, ENSRNOT00000007867.7
    Conserved Domains (3) summary
    COG4886
    Location:39 → 412
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:33 → 232
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:61 → 83
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    87120281..87289748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081880.2 → XP_038937808.1  leucine-rich repeat-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A6I1G1
    Related
    ENSRNOP00000089048.1, ENSRNOT00000104526.2
    Conserved Domains (2) summary
    PRK15370
    Location:26 → 285
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:61 → 83
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_063265888.1 → XP_063121958.1  leucine-rich repeat-containing protein 1 isoform X4

  3. XM_039081882.2 → XP_038937810.1  leucine-rich repeat-containing protein 1 isoform X3

    Conserved Domains (2) summary
    COG4886
    Location:123 → 281
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:133 → 155
    LRR_RI; leucine-rich repeat [structural motif]

  4. XM_039081881.2 → XP_038937809.1  leucine-rich repeat-containing protein 1 isoform X2

    Conserved Domains (2) summary
    COG4886
    Location:123 → 281
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:133 → 155
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_010054010.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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