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Cep70 centrosomal protein 70 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367153, updated on 10-Oct-2024

Summary

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Official Symbol
Cep70provided by RGD
Official Full Name
centrosomal protein 70provided by RGD
Primary source
RGD:1561486
See related
EnsemblRapid:ENSRNOG00000022845 AllianceGenome:RGD:1561486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly and regulation of microtubule cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be active in centrosome. Orthologous to human CEP70 (centrosomal protein 70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 124.6), Kidney (RPKM 69.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep70 in Genome Data Viewer
Location:
8q31
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108689562..108742620)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99810270..99863279)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107495326..107548274)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S4, pseudogene 1 Neighboring gene Fas apoptotic inhibitory molecule like Neighboring gene DnaJ heat shock protein family (Hsp40) member C8, pseudogene 3 Neighboring gene extended synaptotagmin 3 Neighboring gene uncharacterized LOC134480219 Neighboring gene muscle RAS oncogene homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
  3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
centrosomal protein of 70 kDa
Names
centrosomal protein 70kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428871.1 → NP_001415800.1  centrosomal protein of 70 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K3U9, A6I2D0

  2. NM_001428872.1 → NP_001415801.1  centrosomal protein of 70 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K3U9, A6I2D0

  3. NM_001428873.1 → NP_001415802.1  centrosomal protein of 70 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5PQQ9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    108689562..108742620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265896.1 → XP_063121966.1  centrosomal protein of 70 kDa isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3U9, A6I2D0

  2. XM_063265900.1 → XP_063121970.1  centrosomal protein of 70 kDa isoform X4

    UniProtKB/Swiss-Prot
    Q5PQQ9
    Related
    ENSRNOP00000072786.2, ENSRNOT00000081029.3

  3. XM_063265891.1 → XP_063121961.1  centrosomal protein of 70 kDa isoform X1

  4. XM_063265895.1 → XP_063121965.1  centrosomal protein of 70 kDa isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3U9, A6I2D0

  5. XM_063265890.1 → XP_063121960.1  centrosomal protein of 70 kDa isoform X1

  6. XM_063265899.1 → XP_063121969.1  centrosomal protein of 70 kDa isoform X3

  7. XM_006243635.3 → XP_006243697.1  centrosomal protein of 70 kDa isoform X2

    Conserved Domains (1) summary
    COG0419
    Location:85 → 348
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

  8. XM_006243639.3 → XP_006243701.1  centrosomal protein of 70 kDa isoform X4

    Related
    ENSRNOP00000053430.2, ENSRNOT00000056590.6
    Conserved Domains (1) summary
    PRK12704
    Location:76 → 199
    PRK12704; phosphodiesterase; Provisional

  9. XM_063265897.1 → XP_063121967.1  centrosomal protein of 70 kDa isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3U9, A6I2D0

  10. XM_063265901.1 → XP_063121971.1  centrosomal protein of 70 kDa isoform X4

    UniProtKB/Swiss-Prot
    Q5PQQ9

  11. XM_063265894.1 → XP_063121964.1  centrosomal protein of 70 kDa isoform X2

    Related
    ENSRNOP00000099784.1, ENSRNOT00000153468.1

  12. XM_063265892.1 → XP_063121962.1  centrosomal protein of 70 kDa isoform X1

  13. XM_063265903.1 → XP_063121973.1  centrosomal protein of 70 kDa isoform X7

    Related
    ENSRNOP00000109250.1, ENSRNOT00000156249.1

  14. XM_006243640.5 → XP_006243702.1  centrosomal protein of 70 kDa isoform X5

    UniProtKB/TrEMBL
    A0A0G2JU00
    Related
    ENSRNOP00000105102.1, ENSRNOT00000121355.1
    Conserved Domains (1) summary
    COG0419
    Location:42 → 305
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

  15. XM_063265902.1 → XP_063121972.1  centrosomal protein of 70 kDa isoform X6

  16. XM_008766556.3 → XP_008764778.1  centrosomal protein of 70 kDa isoform X8

  17. XM_063265904.1 → XP_063121974.1  centrosomal protein of 70 kDa isoform X9

RNA

  1. XR_010054011.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PQQ9.1 GenPept UniProtKB/Swiss-Prot:Q5PQQ9

Gene LinkOut

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