U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Map4 microtubule-associated protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 367171, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
Map4provided by RGD
Official Full Name
microtubule-associated protein 4provided by RGD
Primary source
RGD:1564359
See related
Ensembl:ENSRNOG00000020748 AllianceGenome:RGD:1564359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mtap4
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of non-motile cilium assembly; and neuron projection development. Predicted to act upstream of or within cell division; microtubule cytoskeleton organization; and microtubule sliding. Located in axon. Orthologous to human MAP4 (microtubule associated protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 577.6), Heart (RPKM 378.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Map4 in Genome Data Viewer
Location:
8q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118800393..118942805)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109925233..110064370)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118013584..118159934)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cathelicidin antimicrobial peptide Neighboring gene cell division cycle 25A Neighboring gene DExH-box helicase 30 Neighboring gene uncharacterized LOC134480238 Neighboring gene small nucleolar RNA SNORA43

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes. Hu J, et al. Cell Death Dis, 2014 Sep 18. PMID 25232678, Free PMC Article
  2. MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1. Fang YD, et al. PLoS One, 2011. PMID 22164227, Free PMC Article
  3. MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Samora CP, et al. Nat Cell Biol, 2011 Aug 7. PMID 21822276
  4. Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length. Ghossoub R, et al. J Cell Sci, 2013 Jun 15. PMID 23572511, Free PMC Article
  5. Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. Ebneth A, et al. Cell Motil Cytoskeleton, 1999 Nov. PMID 10542369

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When targeted to mitochondria, MAP4 was found to lead to mPTP opening and induce apoptosis.
    Title: Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes.
  2. there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization
    Title: MAP4 mechanism that stabilizes mitochondrial permeability transition in hypoxia: microtubule enhancement and DYNLT1 interaction with VDAC1.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule stabilizing activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium disassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within microtubule sliding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
microtubule-associated protein 4
Names
MAP-4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024278.2 → NP_001019449.1  microtubule-associated protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001019449.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5M7W5, Q75NR5, Q75NR6
    UniProtKB/TrEMBL
    A0A8I6AEN3

  2. NM_001419953.1 → NP_001406882.1  microtubule-associated protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AKJ8
    Related
    ENSRNOP00000095817.1, ENSRNOT00000109752.1

  3. NM_001419954.1 → NP_001406883.1  microtubule-associated protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6AKJ8, A0A8L2QPR2, A6I3D0
    Related
    ENSRNOP00000053011.5, ENSRNOT00000056166.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118800393..118942805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243813.5 → XP_006243875.1  microtubule-associated protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (1) summary
    pfam00418
    Location:2042 → 2071
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  2. XM_006243815.5 → XP_006243877.1  microtubule-associated protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (1) summary
    pfam00418
    Location:2042 → 2071
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  3. XM_006243814.5 → XP_006243876.1  microtubule-associated protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (1) summary
    pfam00418
    Location:2042 → 2071
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  4. XM_006243816.5 → XP_006243878.1  microtubule-associated protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JW88, A0A8I6ART8
    Related
    ENSRNOP00000069786.1
    Conserved Domains (1) summary
    pfam00418
    Location:2042 → 2071
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  5. XM_017595795.3 → XP_017451284.1  microtubule-associated protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ART8

  6. XM_006243818.5 → XP_006243880.1  microtubule-associated protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (1) summary
    pfam00418
    Location:2004 → 2033
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  7. XM_063265908.1 → XP_063121978.1  microtubule-associated protein 4 isoform X7

    UniProtKB/TrEMBL
    A0A8I6ART8

  8. XM_039082631.2 → XP_038938559.1  microtubule-associated protein 4 isoform X8

    UniProtKB/TrEMBL
    A0A8I6ART8
    Related
    ENSRNOP00000081853.1
    Conserved Domains (3) summary
    PHA03247
    Location:1686 → 1980
    PHA03247; large tegument protein UL36; Provisional
    TIGR03835
    Location:12 → 440
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam00418
    Location:2004 → 2034
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  9. XM_063265909.1 → XP_063121979.1  microtubule-associated protein 4 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZTS3, A0A8I6ART8

  10. XM_006243819.5 → XP_006243881.1  microtubule-associated protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (1) summary
    pfam00418
    Location:2004 → 2033
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  11. XM_063265910.1 → XP_063121980.1  microtubule-associated protein 4 isoform X12

    UniProtKB/TrEMBL
    A0A8I6ART8

  12. XM_039082632.2 → XP_038938560.1  microtubule-associated protein 4 isoform X11

    UniProtKB/TrEMBL
    A0A8I6ART8
    Related
    ENSRNOP00000080376.1
    Conserved Domains (2) summary
    PHA03247
    Location:1686 → 1980
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:2004 → 2034
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  13. XM_063265911.1 → XP_063121981.1  microtubule-associated protein 4 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZSY4, A0A8I6ART8

  14. XM_006243820.5 → XP_006243882.1  microtubule-associated protein 4 isoform X14

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (1) summary
    pfam00418
    Location:1968 → 1997
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  15. XM_039082633.2 → XP_038938561.1  microtubule-associated protein 4 isoform X15

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (3) summary
    PHA03247
    Location:1687 → 1964
    PHA03247; large tegument protein UL36; Provisional
    TIGR03835
    Location:12 → 440
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam00418
    Location:1968 → 1998
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  16. XM_063265912.1 → XP_063121982.1  microtubule-associated protein 4 isoform X16

    UniProtKB/TrEMBL
    A0A8I6ART8

  17. XM_039082634.2 → XP_038938562.1  microtubule-associated protein 4 isoform X17

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (3) summary
    TIGR03835
    Location:12 → 440
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam05109
    Location:1743 → 2031
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00418
    Location:1930 → 1960
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  18. XM_063265914.1 → XP_063121984.1  microtubule-associated protein 4 isoform X19

    UniProtKB/TrEMBL
    A0A8I6ART8

  19. XM_039082635.2 → XP_038938563.1  microtubule-associated protein 4 isoform X18

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (3) summary
    PHA03247
    Location:1686 → 1894
    PHA03247; large tegument protein UL36; Provisional
    TIGR03835
    Location:12 → 440
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam00418
    Location:1930 → 1960
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  20. XM_063265915.1 → XP_063121985.1  microtubule-associated protein 4 isoform X20

    UniProtKB/TrEMBL
    A0A8I6ART8

  21. XM_039082636.2 → XP_038938564.1  microtubule-associated protein 4 isoform X21

    UniProtKB/TrEMBL
    A0A8I6ART8
    Conserved Domains (3) summary
    PHA03247
    Location:1686 → 1894
    PHA03247; large tegument protein UL36; Provisional
    TIGR03835
    Location:12 → 440
    termin_org_DnaJ; terminal organelle assembly protein TopJ
    pfam00418
    Location:1930 → 1960
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  22. XM_006243821.5 → XP_006243883.1  microtubule-associated protein 4 isoform X22

    UniProtKB/TrEMBL
    A0A8I6AKJ8
    Conserved Domains (1) summary
    pfam00418
    Location:966 → 995
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  23. XM_063265916.1 → XP_063121986.1  microtubule-associated protein 4 isoform X23

    UniProtKB/TrEMBL
    A0A8I6AKJ8

  24. XM_006243823.5 → XP_006243885.1  microtubule-associated protein 4 isoform X24

    UniProtKB/TrEMBL
    A0A8I6AEN3
    Related
    ENSRNOP00000091971.1
    Conserved Domains (1) summary
    pfam00418
    Location:928 → 957
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  25. XM_063265917.1 → XP_063121987.1  microtubule-associated protein 4 isoform X25

    UniProtKB/TrEMBL
    A0A8I6AEN3

  26. XM_063265918.1 → XP_063121988.1  microtubule-associated protein 4 isoform X26

    UniProtKB/TrEMBL
    A0A8I6AEN3

  27. XM_063265920.1 → XP_063121990.1  microtubule-associated protein 4 isoform X27

    UniProtKB/TrEMBL
    A0A8I6AEN3

  28. XM_039082639.2 → XP_038938567.1  microtubule-associated protein 4 isoform X28

    UniProtKB/TrEMBL
    A0A8I6AKJ8
    Conserved Domains (2) summary
    PHA03307
    Location:547 → 892
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:892 → 922
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  29. XM_063265921.1 → XP_063121991.1  microtubule-associated protein 4 isoform X29

    UniProtKB/TrEMBL
    A0A8I6AKJ8

  30. XM_063265922.1 → XP_063121992.1  microtubule-associated protein 4 isoform X30

    UniProtKB/TrEMBL
    A0A8I6AKJ8

  31. XM_063265923.1 → XP_063121993.1  microtubule-associated protein 4 isoform X31

    UniProtKB/TrEMBL
    A0A8I6AEN3

  32. XM_063265935.1 → XP_063122005.1  microtubule-associated protein 4 isoform X46

  33. XM_063265937.1 → XP_063122007.1  microtubule-associated protein 4 isoform X47

  34. XM_063265932.1 → XP_063122002.1  microtubule-associated protein 4 isoform X43

  35. XM_039082641.2 → XP_038938569.1  microtubule-associated protein 4 isoform X39

    Related
    ENSRNOP00000081325.1
    Conserved Domains (2) summary
    PHA03247
    Location:478 → 740
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:744 → 774
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  36. XM_063265930.1 → XP_063122000.1  microtubule-associated protein 4 isoform X41

  37. XM_063265933.1 → XP_063122003.1  microtubule-associated protein 4 isoform X44

  38. XM_063265934.1 → XP_063122004.1  microtubule-associated protein 4 isoform X45

  39. XM_063265929.1 → XP_063121999.1  microtubule-associated protein 4 isoform X40

  40. XM_063265931.1 → XP_063122001.1  microtubule-associated protein 4 isoform X42

    UniProtKB/TrEMBL
    A0A8I5ZRQ1

  41. XM_039082640.2 → XP_038938568.1  microtubule-associated protein 4 isoform X32

    Conserved Domains (2) summary
    PHA03247
    Location:508 → 756
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:818 → 848
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

  42. XM_017595797.3 → XP_017451286.1  microtubule-associated protein 4 isoform X37

  43. XM_017595796.3 → XP_017451285.1  microtubule-associated protein 4 isoform X35

    Related
    ENSRNOP00000095245.1

  44. XM_063265928.1 → XP_063121998.1  microtubule-associated protein 4 isoform X38

  45. XM_063265926.1 → XP_063121996.1  microtubule-associated protein 4 isoform X36

    UniProtKB/TrEMBL
    A0A8I6AL32

  46. XM_063265924.1 → XP_063121994.1  microtubule-associated protein 4 isoform X33

  47. XM_063265925.1 → XP_063121995.1  microtubule-associated protein 4 isoform X34

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M7W5.1 GenPept UniProtKB/Swiss-Prot:Q5M7W5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials