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Rp2 RP2 activator of ARL3 GTPase [ Rattus norvegicus (Norway rat) ]

Gene ID: 367714, updated on 14-Nov-2024

Summary

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Official Symbol
Rp2provided by RGD
Official Full Name
RP2 activator of ARL3 GTPaseprovided by RGD
Primary source
RGD:1565124
See related
EnsemblRapid:ENSRNOG00000025428 AllianceGenome:RGD:1565124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rp2h; RGD1565124
Summary
Predicted to enable GTPase activator activity and magnesium ion binding activity. Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be located in several cellular components, including Golgi apparatus; microtubule organizing center; and nuclear body. Predicted to be active in cilium and periciliary membrane compartment. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 82.3), Lung (RPKM 76.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rp2 in Genome Data Viewer
Location:
Xq11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (4426071..4470200, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1872582..1916704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (2066298..2116661, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 1, pseudogene 1 Neighboring gene jade family PHD finger 3 Neighboring gene solute carrier family 25 member 39, pseudogene 2 Neighboring gene ribosomal protein L7, pseudogene 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. X-linked retinitis pigmentosa: mutation spectrum of the RPGR and RP2 genes and correlation with visual function. Sharon D, et al. Invest Ophthalmol Vis Sci, 2000 Aug. PMID 10937588
  2. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Veltel S, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18376416
  3. The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Evans RJ, et al. Hum Mol Genet, 2010 Apr 1. PMID 20106869
  4. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Grayson C, et al. Hum Mol Genet, 2002 Nov 15. PMID 12417528
  5. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. Bartolini F, et al. J Biol Chem, 2002 Apr 26. PMID 11847227

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in post-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within post-Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in post-chaperonin tubulin folding pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in periciliary membrane compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in periciliary membrane compartment ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein XRP2
Names
RP2, ARL3 GTPase activating protein
retinitis pigmentosa 2 (X-linked recessive)
retinitis pigmentosa 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109012.2 → NP_001102482.1  protein XRP2

    See identical proteins and their annotated locations for NP_001102482.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A6JZU1, A6JZU2, D3ZTJ0
    Related
    ENSRNOP00000051952.5, ENSRNOT00000055077.6
    Conserved Domains (2) summary
    smart00562
    Location:250 → 310
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    pfam07986
    Location:59 → 177
    TBCC; Tubulin binding cofactor C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    4426071..4470200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099932.2 → XP_038955860.1  protein XRP2 isoform X1

    UniProtKB/TrEMBL
    A6JZU1, A6JZU2, D3ZTJ0
    Conserved Domains (2) summary
    smart00562
    Location:250 → 310
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    pfam07986
    Location:59 → 177
    TBCC; Tubulin binding cofactor C
Nucleotide Protein Strain
Heading Accession and Version

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