Pnn pinin, desmosome associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnnprovided by RGD
Official Full Name: pinin, desmosome associated proteinprovided by RGD
Primary source: RGD:1597086
See related: EnsemblRapid:ENSRNOG00000004061 AllianceGenome:RGD:1597086
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in cytoplasm; desmosome; and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and exon-exon junction complex. Orthologous to human PNN (pinin, desmosome associated protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Thymus (RPKM 213.0), Spleen (RPKM 179.9) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6q23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (82493032..82501345)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (76758138..76766451)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (80159364..80167677)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous Pnn participates in neuroprotection after acute ischemic stroke by preserving the viability of astrocytes that survived the ischemic challenge via maintenance of mitochondrial anti-apoptotic and bioenergetics functions.
Title: Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

G54093 (e-PCR)
- UniSTS:109330

NoName (e-PCR)
- UniSTS:532324

Pnn (e-PCR), detects polymorphism
- UniSTS:532324

AA818736 (e-PCR)
- UniSTS:249722

D12Ertd512e (e-PCR), detects polymorphism
- UniSTS:167090

AU045199 (e-PCR)
- UniSTS:160211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: pinin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109023.1 → NP_001102493.1 pinin

See identical proteins and their annotated locations for NP_001102493.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HBR2, D3ZAY8

Related

ENSRNOP00000005439.7, ENSRNOT00000005439.7

Conserved Domains (3) summary

pfam04696
Location:136 → 261

Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region

pfam04697
Location:5 → 132

Pinin_SDK_N; pinin/SDK conserved region

pfam14650
Location:491 → 537

FAM75; FAM75 family