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Gbp2 Growth-blocking peptide 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36937, updated on 2-Nov-2024

Summary

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Official Symbol
Gbp2provided by FlyBase
Official Full Name
Growth-blocking peptide 2provided by FlyBase
Primary source
FLYBASE:FBgn0034200
Locus tag
Dmel_CG11395
See related
AllianceGenome:FB:FBgn0034200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11395; Dmel\CG11395; GBP; gbp2; GBP2; GBPs
Summary
Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Located in extracellular region. Is expressed in adult fat body; amnioserosa; embryonic/larval fat body; and yolk nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Gbp2 in Genome Data Viewer
Location:
54A1-54A1; 2-82 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17137240..17139595)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13024745..13027100)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Growth-blocking peptide 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44386 Neighboring gene uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10. Ono M, et al. Insect Biochem Mol Biol, 2024 Apr. PMID 38295885,
  2. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation. Koyama T, et al. PLoS Biol, 2016 Feb. PMID 26928023, Free PMC Article
  3. An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila. Meschi E, et al. Dev Cell, 2019 Jan 7. PMID 30555002
  4. SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. Vorobyeva NE, et al. Cell Cycle, 2011 Jun 1. PMID 21519192
  5. Population transcriptomics of Drosophila melanogaster females. Müller L, et al. BMC Genomics, 2011 Jan 28. PMID 21276238, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region HDA PubMed 

General protein information

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Preferred Names
Growth-blocking peptide 2
Names
CG11395-PA
CG11395-PB
Gbp2-PA
Gbp2-PB
Growth-Blocking peptide 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17137240..17139595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299592.1 → NP_001286521.1  Growth-blocking peptide 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K533
    Conserved Domains (2) summary
    PTZ00395
    Location:124 → 428
    PTZ00395; Sec24-related protein; Provisional
    PRK14086
    Location:26 → 204
    dnaA; chromosomal replication initiation protein; Provisional

  2. NM_137351.3 → NP_611195.1  Growth-blocking peptide 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611195.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K533
    Related
    FBpp0086140
    Conserved Domains (2) summary
    PTZ00395
    Location:124 → 428
    PTZ00395; Sec24-related protein; Provisional
    PRK14086
    Location:26 → 204
    dnaA; chromosomal replication initiation protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K533 Q7K533

Gene LinkOut

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