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Ift81 intraflagellar transport 81 [ Rattus norvegicus (Norway rat) ]

Gene ID: 373066, updated on 6-Jun-2024

Summary

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Official Symbol
Ift81provided by RGD
Official Full Name
intraflagellar transport 81provided by RGD
Primary source
RGD:727862
See related
Ensembl:ENSRNOG00000001294 AllianceGenome:RGD:727862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdv1; Cdv-1
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly; regulation of smoothened signaling pathway; and spermatogenesis. Predicted to be located in ciliary basal body; sperm midpiece; and sperm principal piece. Predicted to be part of intraciliary transport particle B. Predicted to be active in centrosome and cilium. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Orthologous to human IFT81 (intraflagellar transport 81). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 128.4), Heart (RPKM 122.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift81 in Genome Data Viewer
Location:
12q16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39618559..39697971)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33957744..34037164)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39420161..39507412)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32, pseudogene 11 Neighboring gene purinergic receptor P2X 7 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene ribosomal protein L38, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome. Duran I, et al. Sci Rep, 2016 Sep 26. PMID 27666822, Free PMC Article
  2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Bhogaraju S, et al. Science, 2013 Aug 30. PMID 23990561, Free PMC Article
  3. Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation. Peng J, et al. Mol Biol Rep, 2002 Dec. PMID 12549821
  4. Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene. Higashi M, et al. Mamm Genome, 2000 Dec. PMID 11130971
  5. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Howard PW, et al. Exp Cell Res, 2013 Aug 15. PMID 23810713, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport involved in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sperm flagellum assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm flagellum assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm flagellum assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm midpiece IEA
Inferred from Electronic Annotation
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
  
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 81 homolog
Names
carnitine deficiency-associated gene expressed in ventricle 1
carnitine deficiency-associated protein expressed in ventricle 1
intraflagellar transport 81 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199120.2 → NP_954551.2  intraflagellar transport protein 81 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P83829
    UniProtKB/TrEMBL
    A0A8I6A5Q9, A6J187
    Related
    ENSRNOP00000088207.1, ENSRNOT00000110153.1
    Conserved Domains (3) summary
    COG1196
    Location:340 → 621
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:141 → 406
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam18383
    Location:3 → 126
    IFT81_CH; Intraflagellar transport 81 calponin homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    39618559..39697971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089655.1 → XP_038945583.1  intraflagellar transport protein 81 homolog isoform X2

    UniProtKB/Swiss-Prot
    P83829
    UniProtKB/TrEMBL
    D4A562
    Related
    ENSRNOP00000061697.3, ENSRNOT00000066952.3
    Conserved Domains (3) summary
    COG1196
    Location:340 → 621
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:141 → 406
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam18383
    Location:3 → 126
    IFT81_CH; Intraflagellar transport 81 calponin homology domain

  2. XM_039089656.2 → XP_038945584.1  intraflagellar transport protein 81 homolog isoform X3

    UniProtKB/Swiss-Prot
    P83829
    Conserved Domains (3) summary
    COG1196
    Location:340 → 621
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:141 → 406
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam18383
    Location:3 → 126
    IFT81_CH; Intraflagellar transport 81 calponin homology domain

  3. XM_039089654.2 → XP_038945582.1  intraflagellar transport protein 81 homolog isoform X1

    UniProtKB/Swiss-Prot
    P83829
    UniProtKB/TrEMBL
    A0A8I6A5Q9, A6J187
    Conserved Domains (3) summary
    COG1196
    Location:340 → 621
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:141 → 406
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam18383
    Location:3 → 126
    IFT81_CH; Intraflagellar transport 81 calponin homology domain

  4. XM_063271568.1 → XP_063127638.1  intraflagellar transport protein 81 homolog isoform X2

    UniProtKB/Swiss-Prot
    P83829
    UniProtKB/TrEMBL
    D4A562

  5. XM_063271569.1 → XP_063127639.1  intraflagellar transport protein 81 homolog isoform X3

    UniProtKB/Swiss-Prot
    P83829
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83829.1 GenPept UniProtKB/Swiss-Prot:P83829

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