U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD82 CD82 molecule [ Homo sapiens (human) ]

Gene ID: 3732, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CD82provided by HGNC
Official Full Name
CD82 moleculeprovided by HGNC
Primary source
HGNC:HGNC:6210
See related
Ensembl:ENSG00000085117 MIM:600623; AllianceGenome:HGNC:6210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27
Summary
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 44.7), bone marrow (RPKM 32.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CD82 in Genome Data Viewer
Location:
11p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (44564409..44620358)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (44720425..44776379)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44587213..44641908)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44550187-44551103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44556450-44556973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44556974-44557496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3273 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:44561345-44561951 Neighboring gene ribosomal protein L7a pseudogene 79 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3274 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:44580713-44581349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44583385-44583886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44583887-44584386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44587226-44587726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4657 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44617773-44618351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44618352-44618931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44619920-44620420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44620421-44620921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44622959-44623562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44630450-44630950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3277 Neighboring gene CD82 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44656670-44657458 Neighboring gene ribosomal protein L34 pseudogene 22 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44675065-44675680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44676298-44676913 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:44685723-44686240 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44692285-44693064 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44693065-44693844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:44693845-44694623 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:44710524-44711057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:44713680-44714180 Neighboring gene long intergenic non-protein coding RNA 2704

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal-fetal interface: Regulation and functional implications. Gellersen B, et al. Am J Pathol, 2007 Jan. PMID 17200188, Free PMC Article
  2. Alternative splicing of KAI1 abrogates its tumor-suppressive effects on integrin αvβ3-mediated ovarian cancer biology. Upheber S, et al. Cell Signal, 2015 Mar. PMID 25435431
  3. KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. Christgen M, et al. Int J Cancer, 2008 Nov 15. PMID 18712725
  4. Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma. Protzel C, et al. Virchows Arch, 2008 Apr. PMID 18305955
  5. KAI1 gene suppresses invasion and metastasis of hepatocellular carcinoma MHCC97-H cells in vitro and in animal models. Yang JM, et al. Liver Int, 2008 Jan. PMID 18028322

See all (234) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA Hypermethylation Inhibits the CD82 Metastasis Suppressor Gene in Gastric Cancer.
    Title: DNA Hypermethylation Inhibits the CD82 Metastasis Suppressor Gene in Gastric Cancer.
  2. CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.
    Title: CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.
  3. Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.
    Title: Tetraspanin CD82 Correlates with and May Regulate S100A7 Expression in Oral Cancer.
  4. Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
    Title: Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.
  5. Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
    Title: Expression of KAI1 and AGR2 in lung adenocarcinoma and their clinicopathological significance.
  6. Lower expression of KAI1 as a biomarker of poor survival prognosis of melanoma combined with colorectal cancer metastasis.
    Title: Lower expression of KAI1 as a biomarker of poor survival prognosis of melanoma combined with colorectal cancer metastasis.
  7. Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
    Title: Proteomic profiling of plasma exosomes reveals CD82 involvement in the development of esophageal squamous cell carcinoma.
  8. A positive COX-2/IL-1beta loop promotes decidualization by upregulating CD82.
    Title: A positive COX-2/IL-1β loop promotes decidualization by upregulating CD82.
  9. The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
    Title: The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma.
  10. CD82 is a marker to isolate beta cell precursors from human iPS cells and plays a role for the maturation of beta cells.
    Title: CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells.
Submit: New GeneRIF Correction See all GeneRIFs (174)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
EBI GWAS Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD82 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
Envelope surface glycoprotein gp160, precursor env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
env CD82 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles PubMed
env DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures PubMed
Pr55(Gag) gag HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains PubMed
gag DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures PubMed
Vpu vpu HIV-1 Vpu is the main determinant for the overall downregulation of CD82 in HIV-1-infected CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
CD82 antigen
Names
C33 antigen
inducible membrane protein R2
kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
metastasis suppressor Kangai-1
tetraspanin-27
tspan-27

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023234.1 RefSeqGene

    Range
    5073..59768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024844.2 → NP_001020015.1  CD82 antigen isoform 2

    See identical proteins and their annotated locations for NP_001020015.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks a segment in the middle region, as compared to isoform 1.
    Source sequence(s)
    AC010768, AY303776, CB127804, U20770
    Consensus CDS
    CCDS31469.1
    UniProtKB/TrEMBL
    Q6LET0
    Related
    ENSP00000339686.3, ENST00000342935.7
    Conserved Domains (2) summary
    cd03160
    Location:86 → 204
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:24 → 231
    Tetraspannin; Tetraspanin family

  2. NM_002231.4 → NP_002222.1  CD82 antigen isoform 1

    See identical proteins and their annotated locations for NP_002222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010768, CB127804, U20770
    Consensus CDS
    CCDS7909.1
    UniProtKB/Swiss-Prot
    D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2
    UniProtKB/TrEMBL
    Q6LET0
    Related
    ENSP00000227155.4, ENST00000227155.9
    Conserved Domains (2) summary
    cd03160
    Location:106 → 229
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:24 → 256
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    44564409..44620358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426900.1 → XP_047282856.1  CD82 antigen isoform X1

  2. XM_047426901.1 → XP_047282857.1  CD82 antigen isoform X2

  3. XM_047426903.1 → XP_047282859.1  CD82 antigen isoform X3

    UniProtKB/Swiss-Prot
    D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

  4. XM_047426904.1 → XP_047282860.1  CD82 antigen isoform X3

    UniProtKB/Swiss-Prot
    D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

  5. XM_011520067.3 → XP_011518369.1  CD82 antigen isoform X4

    UniProtKB/TrEMBL
    Q6LET0
    Related
    ENST00000530931.2
    Conserved Domains (2) summary
    cd03160
    Location:75 → 198
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:23 → 225
    Tetraspannin; Tetraspanin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    44720425..44776379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368698.1 → XP_054224673.1  CD82 antigen isoform X1

  2. XM_054368699.1 → XP_054224674.1  CD82 antigen isoform X2

  3. XM_054368700.1 → XP_054224675.1  CD82 antigen isoform X3

    UniProtKB/Swiss-Prot
    D3DQN6, E9PC70, P27701, Q7Z2D4, Q7Z5N2

  4. XM_054368701.1 → XP_054224676.1  CD82 antigen isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27701.1 GenPept UniProtKB/Swiss-Prot:P27701

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools