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Stk25 serine/threonine kinase 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 373542, updated on 2-Nov-2024

Summary

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Official Symbol
Stk25provided by RGD
Official Full Name
serine/threonine kinase 25provided by RGD
Primary source
RGD:727809
See related
EnsemblRapid:ENSRNOG00000018181 AllianceGenome:RGD:727809
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including establishment of Golgi localization; intrinsic apoptotic signaling pathway in response to hydrogen peroxide; and positive regulation of stress-activated MAPK cascade. Predicted to act upstream of or within several processes, including Golgi localization; positive regulation of axonogenesis; and protein phosphorylation. Located in Golgi membrane. Orthologous to human STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 417.4), Lung (RPKM 316.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stk25 in Genome Data Viewer
Location:
9q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101609218..101621458, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94161834..94174095, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100767578..100779715, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene septin 2 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 2 Neighboring gene 5S ribosomal RNA Neighboring gene BCL2 family apoptosis regulator BOK Neighboring gene THAP domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle. Nerstedt A, et al. Diabetologia, 2012 Jun. PMID 22391949
  2. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. Pombo CM, et al. EMBO J, 1996 Sep 2. PMID 8887545, Free PMC Article
  3. PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress. Zhang H, et al. Front Biosci (Landmark Ed), 2012 Jun 1. PMID 22652780
  4. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Zhou J, et al. Mol Cell Biol, 2009 Aug. PMID 19451227, Free PMC Article
  5. YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. Preisinger C, et al. J Cell Biol, 2004 Mar 29. PMID 15037601, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study indicates a possible role for STK25 in the regulation of glucose and lipid metabolism in L6 myoblasts.
    Title: Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC94619

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi reassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 25
Names
serine/threonine kinase 25 (STE20 homolog, yeast)
NP_908938.1
XP_038939953.1
XP_038939955.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_184049.1 → NP_908938.1  serine/threonine-protein kinase 25

    See identical proteins and their annotated locations for NP_908938.1

    Status: PROVISIONAL

    Source sequence(s)
    AY346152
    UniProtKB/TrEMBL
    A0A8I5ZQ80, F7ERC6, Q6V9V9
    Related
    ENSRNOP00000024487.4, ENSRNOT00000024487.6
    Conserved Domains (1) summary
    cd06642
    Location:15 → 291
    STKc_STK25; Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    101609218..101621458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084025.2 → XP_038939953.1  serine/threonine-protein kinase 25 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 197
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039084027.2 → XP_038939955.1  serine/threonine-protein kinase 25 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:15 → 257
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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