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Panx Panoramix [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37434, updated on 24-Oct-2024

Summary

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Official Symbol
Panxprovided by FlyBase
Official Full Name
Panoramixprovided by FlyBase
Primary source
FLYBASE:FBgn0034617
Locus tag
Dmel_CG9754
See related
AllianceGenome:FB:FBgn0034617
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9754; Dmel\CG9754; pan; panx
Summary
Enables piRNA binding activity. Involved in several processes, including gene silencing by RNA; piRNA biosynthetic process; and positive regulation of DNA methylation-dependent heterochromatin assembly. Located in nucleus. Part of transcription repressor complex. Is expressed in organism. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Panx in Genome Data Viewer
Location:
57D11-57D11; 2-94 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21310368..21312354, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17197873..17199859, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44724 Neighboring gene Ankyrin repeat-rich membrane spanning Neighboring gene antisense RNA:CR45149 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis. Fabry MH, et al. Elife, 2021 Jul 8. PMID 34236313, Free PMC Article
  2. piRNA-guided co-transcriptional silencing coopts nuclear export factors. Fabry MH, et al. Elife, 2019 Jun 20. PMID 31219034, Free PMC Article
  3. piRNA-independent transposon silencing by the Drosophila THO complex. Zhang G, et al. Dev Cell, 2021 Sep 27. PMID 34547226, Free PMC Article
  4. The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation. Batki J, et al. Nat Struct Mol Biol, 2019 Aug. PMID 31384064, Free PMC Article
  5. Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Yang F, et al. Elife, 2019 Jan 16. PMID 30648969, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
    Title: Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.
  2. SFiNX, an interdependent protein complex, is required for Piwi-mediated cotranscriptional silencing in Drosophila. SFiNX consists of Nxf2-Nxt1, a gonad-specific variant of the heterodimeric messenger RNA export receptor Nxf1-Nxt1 and the Piwi-associated protein Panoramix. Within SFiNX, Panoramix recruits heterochromatin effectors, while the RNA binding protein Nxf2 licenses cotranscriptional silencing.
    Title: The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation.
  3. The transposon RNA-binding protein Nxf2 is required for animal fertility and Panoramix-mediated silencing.
    Title: A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation.
  4. CG9754/Silencio as an essential piRNA pathway factor that is required for Piwi-mediated transcriptional silencing in Drosophila
    Title: Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery.
  5. this study sshow that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcriptional silencing.
    Title: Panoramix enforces piRNA-dependent cotranscriptional silencing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables piRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in piRNA-mediated heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrotransposon silencing by heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription repressor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
panoramix
Names
CG9754-PA
Panx-PA
silencio

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21310368..21312354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137732.4 → NP_611576.1  panoramix [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611576.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W2H9
    Related
    FBpp0071541
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2H9.1 Q9W2H9

Gene LinkOut

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