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TEX9 testis expressed 9 [ Homo sapiens (human) ]

Gene ID: 374618, updated on 2-Nov-2024

Summary

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Official Symbol
TEX9provided by HGNC
Official Full Name
testis expressed 9provided by HGNC
Primary source
HGNC:HGNC:29585
See related
Ensembl:ENSG00000151575 MIM:620935; AllianceGenome:HGNC:29585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in centriolar satellite. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 5.0), thyroid (RPKM 4.2) and 23 other tissues See more
Orthologs
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Genomic context

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See TEX9 in Genome Data Viewer
Location:
15q21.3
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (56243973..56460010)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (54046826..54262846)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56536171..56738081)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903498 Neighboring gene Sharpr-MPRA regulatory region 1757 Neighboring gene regulatory factor X7 Neighboring gene hydroxyacyl-CoA dehydrogenase pseudogene Neighboring gene MPRA-validated peak2347 silencer Neighboring gene laforin-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:56536049-56536694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:56536695-56537340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:56537341-56537986 Neighboring gene RNA, U6 small nuclear 1287, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:56608633-56609184 Neighboring gene high mobility group box 1 pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9455 Neighboring gene uncharacterized LOC105370832 Neighboring gene Sharpr-MPRA regulatory region 15328 Neighboring gene meiosis specific nuclear structural 1 Neighboring gene zinc finger protein 280D Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6466

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TEX9 and eIF3b functionally synergize to promote the progression of esophageal squamous cell carcinoma. Xu F, et al. BMC Cancer, 2019 Sep 3. PMID 31481019, Free PMC Article
  2. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. Brandler WM, et al. PLoS Genet, 2013. PMID 24068947, Free PMC Article
  3. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Goldstein JI, et al. Nat Commun, 2014 Sep 4. PMID 25187353, Free PMC Article
  4. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article
  5. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. Hunter MR, et al. J Mol Biol, 2018 Jul 6. PMID 29778605, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC40181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-expressed protein 9
Names
testis-expressed sequence 9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286449.2 → NP_001273378.1  testis-expressed protein 9 isoform 2

    See identical proteins and their annotated locations for NP_001273378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    UniProtKB/Swiss-Prot
    Q8N6V9
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001385040.1 → NP_001371969.1  testis-expressed protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_001385041.1 → NP_001371970.1  testis-expressed protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_001385042.1 → NP_001371971.1  testis-expressed protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    Related
    ENSP00000452791.2, ENST00000560827.6
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. NM_001385043.1 → NP_001371972.1  testis-expressed protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. NM_001385044.1 → NP_001371973.1  testis-expressed protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. NM_001385045.1 → NP_001371974.1  testis-expressed protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 3' UTR compared to variant 2. Variants 2-8 all encode the same isoform (2).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS66776.1
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 273
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. NM_001385046.1 → NP_001371975.1  testis-expressed protein 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:146 → 304
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. NM_001385047.1 → NP_001371976.1  testis-expressed protein 9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:190 → 328
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. NM_001385048.1 → NP_001371977.1  testis-expressed protein 9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:71 → 229
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. NM_001385049.1 → NP_001371978.1  testis-expressed protein 9 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:115 → 224
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. NM_001385050.1 → NP_001371979.1  testis-expressed protein 9 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 14 and 15, encodes isoform 7.
    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 145
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  13. NM_001385051.1 → NP_001371980.1  testis-expressed protein 9 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 13 and 15, encodes isoform 7.
    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 145
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  14. NM_001385052.1 → NP_001371981.1  testis-expressed protein 9 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 13 and 14, encodes isoform 7.
    Source sequence(s)
    AC068726, AC084782
    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 145
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  15. NM_001395496.1 → NP_001382425.1  testis-expressed protein 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS10157.1
    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669
    Related
    ENSP00000512397.1, ENST00000696102.1
    Conserved Domains (1) summary
    TIGR02168
    Location:190 → 348
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  16. NM_198524.3 → NP_940926.1  testis-expressed protein 9 isoform 1

    See identical proteins and their annotated locations for NP_940926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC068726, AC084782
    Consensus CDS
    CCDS10157.1
    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669
    Related
    ENSP00000342169.2, ENST00000352903.6
    Conserved Domains (1) summary
    TIGR02168
    Location:190 → 348
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. NR_169560.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782

  2. NR_169561.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782

  3. NR_169562.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782

  4. NR_169563.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068726, AC084782

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    56243973..56460010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432470.1 → XP_047288426.1  testis-expressed protein 9 isoform X4

  2. XM_047432466.1 → XP_047288422.1  testis-expressed protein 9 isoform X1

    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669

  3. XM_047432468.1 → XP_047288424.1  testis-expressed protein 9 isoform X2

  4. XM_047432475.1 → XP_047288431.1  testis-expressed protein 9 isoform X5

  5. XM_011521530.4 → XP_011519832.1  testis-expressed protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011519832.1

    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669
    Conserved Domains (1) summary
    TIGR02168
    Location:190 → 348
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_047432476.1 → XP_047288432.1  testis-expressed protein 9 isoform X5

  7. XM_047432467.1 → XP_047288423.1  testis-expressed protein 9 isoform X2

  8. XM_005254359.6 → XP_005254416.1  testis-expressed protein 9 isoform X1

    See identical proteins and their annotated locations for XP_005254416.1

    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669
    Conserved Domains (1) summary
    TIGR02168
    Location:190 → 348
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_047432474.1 → XP_047288430.1  testis-expressed protein 9 isoform X5

  10. XM_047432469.1 → XP_047288425.1  testis-expressed protein 9 isoform X3

  11. XM_047432472.1 → XP_047288428.1  testis-expressed protein 9 isoform X4

  12. XM_047432471.1 → XP_047288427.1  testis-expressed protein 9 isoform X4

  13. XM_047432473.1 → XP_047288429.1  testis-expressed protein 9 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    54046826..54262846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377869.1 → XP_054233844.1  testis-expressed protein 9 isoform X4

  2. XM_054377866.1 → XP_054233841.1  testis-expressed protein 9 isoform X1

    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669

  3. XM_054377868.1 → XP_054233843.1  testis-expressed protein 9 isoform X2

  4. XM_054377873.1 → XP_054233848.1  testis-expressed protein 9 isoform X5

  5. XM_054377864.1 → XP_054233839.1  testis-expressed protein 9 isoform X1

    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669

  6. XM_054377874.1 → XP_054233849.1  testis-expressed protein 9 isoform X5

  7. XM_054377867.1 → XP_054233842.1  testis-expressed protein 9 isoform X2

  8. XM_054377865.1 → XP_054233840.1  testis-expressed protein 9 isoform X1

    UniProtKB/Swiss-Prot
    B4DH73, Q8N6V9
    UniProtKB/TrEMBL
    A0A0S2Z669

  9. XM_054377872.1 → XP_054233847.1  testis-expressed protein 9 isoform X5

  10. XM_054377870.1 → XP_054233845.1  testis-expressed protein 9 isoform X4

  11. XM_054377871.1 → XP_054233846.1  testis-expressed protein 9 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6V9.1 GenPept UniProtKB/Swiss-Prot:Q8N6V9

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