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ZNF710 zinc finger protein 710 [ Homo sapiens (human) ]

Gene ID: 374655, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF710provided by HGNC
Official Full Name
zinc finger protein 710provided by HGNC
Primary source
HGNC:HGNC:25352
See related
Ensembl:ENSG00000140548 AllianceGenome:HGNC:25352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.2), spleen (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q26.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (89998307..90082191)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87754311..87838222)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90544556..90625423)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90452345-90452529 Neighboring gene RNA, U7 small nuclear 111 pseudogene Neighboring gene actin related protein 2/3 complex inhibitor Neighboring gene zinc finger and SCAN domain containing 5A pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90525469-90526190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6807 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90544586-90544754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90545369-90546137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90546138-90546905 Neighboring gene microRNA 3174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90581285-90581804 Neighboring gene Sharpr-MPRA regulatory region 12348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90585951-90586930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90597371-90598254 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90602135-90602846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90627210-90627710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90627711-90628211 Neighboring gene ZNF710 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90630317-90631230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:90634376-90634876 Neighboring gene NANOG hESC enhancer GRCh37_chr15:90638658-90639182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90644126-90644981 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90644982-90645836 Neighboring gene isocitrate dehydrogenase (NADP(+)) 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90664819-90665318 Neighboring gene IDH2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 4454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90686773-90687307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90701094-90701611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90701612-90702128 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90704142-90704734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:90704735-90705327 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:90707039-90707194 Neighboring gene RNA, 7SL, cytoplasmic 346, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of antisense long non‑coding RNA ZNF710‑AS1‑202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression. Li G, et al. Mol Med Rep, 2020 Jun. PMID 32236626, Free PMC Article
  2. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of antisense long noncoding RNA ZNF710AS1202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression.
    Title: Overexpression of antisense long non‑coding RNA ZNF710‑AS1‑202 promotes cell proliferation and inhibits apoptosis of clear cell renal cell carcinoma via regulation of ZNF710 expression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00306, FLJ37393, MGC163413, DKFZp547K1113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 710

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198526.4 → NP_940928.2  zinc finger protein 710

    See identical proteins and their annotated locations for NP_940928.2

    Status: VALIDATED

    Source sequence(s)
    AC087284, AK160373, AL831826, BC020301, BC126476
    Consensus CDS
    CCDS10358.1
    UniProtKB/Swiss-Prot
    A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0
    Related
    ENSP00000268154.3, ENST00000268154.9
    Conserved Domains (4) summary
    COG5048
    Location:335 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:297 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435 → 457
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:534 → 558
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    89998307..90082191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432486.1 → XP_047288442.1  zinc finger protein 710 isoform X4

  2. XM_011521543.4 → XP_011519845.2  zinc finger protein 710 isoform X6

  3. XM_047432483.1 → XP_047288439.1  zinc finger protein 710 isoform X2

  4. XM_047432482.1 → XP_047288438.1  zinc finger protein 710 isoform X1

  5. XM_005254907.5 → XP_005254964.1  zinc finger protein 710 isoform X3

    See identical proteins and their annotated locations for XP_005254964.1

    Conserved Domains (4) summary
    COG5048
    Location:335 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:297 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435 → 457
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:534 → 558
    zf-H2C2_2; Zinc-finger double domain

  6. XM_047432487.1 → XP_047288443.1  zinc finger protein 710 isoform X5

    UniProtKB/Swiss-Prot
    A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

  7. XM_047432488.1 → XP_047288444.1  zinc finger protein 710 isoform X5

    UniProtKB/Swiss-Prot
    A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

  8. XM_005254906.5 → XP_005254963.1  zinc finger protein 710 isoform X3

    See identical proteins and their annotated locations for XP_005254963.1

    Conserved Domains (4) summary
    COG5048
    Location:335 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:297 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435 → 457
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:534 → 558
    zf-H2C2_2; Zinc-finger double domain

  9. XM_011521542.4 → XP_011519844.1  zinc finger protein 710 isoform X3

    See identical proteins and their annotated locations for XP_011519844.1

    Conserved Domains (4) summary
    COG5048
    Location:335 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:297 → 317
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:435 → 457
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:534 → 558
    zf-H2C2_2; Zinc-finger double domain

  10. XM_047432484.1 → XP_047288440.1  zinc finger protein 710 isoform X3

  11. XM_047432485.1 → XP_047288441.1  zinc finger protein 710 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    87754311..87838222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377888.1 → XP_054233863.1  zinc finger protein 710 isoform X4

  2. XM_054377881.1 → XP_054233856.1  zinc finger protein 710 isoform X1

  3. XM_054377891.1 → XP_054233866.1  zinc finger protein 710 isoform X6

  4. XM_054377882.1 → XP_054233857.1  zinc finger protein 710 isoform X2

  5. XM_054377883.1 → XP_054233858.1  zinc finger protein 710 isoform X3

  6. XM_054377884.1 → XP_054233859.1  zinc finger protein 710 isoform X3

  7. XM_054377886.1 → XP_054233861.1  zinc finger protein 710 isoform X3

  8. XM_054377889.1 → XP_054233864.1  zinc finger protein 710 isoform X5

    UniProtKB/Swiss-Prot
    A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

  9. XM_054377890.1 → XP_054233865.1  zinc finger protein 710 isoform X5

    UniProtKB/Swiss-Prot
    A0AVS3, Q6ZMK9, Q8N1W2, Q8NDU0

  10. XM_054377887.1 → XP_054233862.1  zinc finger protein 710 isoform X3

  11. XM_054377885.1 → XP_054233860.1  zinc finger protein 710 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N1W2.2 GenPept UniProtKB/Swiss-Prot:Q8N1W2

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