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LINC01116 long intergenic non-protein coding RNA 1116 [ Homo sapiens (human) ]

Gene ID: 375295, updated on 10-Mar-2024

Summary

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Official Symbol
LINC01116provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1116provided by HGNC
Primary source
HGNC:HGNC:49259
See related
Ensembl:ENSG00000163364 AllianceGenome:HGNC:49259
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TALNEC2
Expression
Broad expression in ovary (RPKM 6.9), adrenal (RPKM 5.0) and 15 other tissues See more
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Genomic context

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Location:
2q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (176611437..176637609, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (177093539..177119723, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (177494309..177502302, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907910 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:177453489-177454688 Neighboring gene microRNA 1246 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:177485641-177486840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12138 Neighboring gene VISTA enhancer hs248 Neighboring gene long intergenic non-protein coding RNA 1117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12139 Neighboring gene RNA, U6atac small nuclear 14, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma. Wang XK, et al. BMC Gastroenterol, 2023 Jun 20. PMID 37340445, Free PMC Article
  2. The mechanism of lncRNA TALNEC2 regulating miR-19a-3p/JNK to alleviate cerebral ischemia injury in rats with acute cerebral infarction. Luan D, et al. Cell Mol Biol (Noisy-le-grand), 2022 Jun 30. PMID 36227683
  3. Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway. Shang B, et al. Thorac Cancer, 2021 Jul. PMID 34061456, Free PMC Article
  4. LINC01116 facilitates colorectal cancer cell proliferation and angiogenesis through targeting EZH2-regulated TPM1. Liang W, et al. J Transl Med, 2021 Jan 26. PMID 33499872, Free PMC Article
  5. LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell. Wang T, et al. Cell Death Dis, 2020 May 1. PMID 32358484, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia-induced factor-1alpha promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia.
    Title: Hypoxia-induced factor-1α promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia.
  2. LINC01116 affects patient survival differently and is dissimilarly expressed in ER+ and ER- breast cancer samples.
    Title: LINC01116 affects patient survival differently and is dissimilarly expressed in ER+ and ER- breast cancer samples.
  3. Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma.
    Title: Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma.
  4. LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration.
    Title: LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration.
  5. LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma.
    Title: LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma.
  6. The mechanism of lncRNA TALNEC2 regulating miR-19a-3p/JNK to alleviate cerebral ischemia injury in rats with acute cerebral infarction.
    Title: The mechanism of lncRNA TALNEC2 regulating miR-19a-3p/JNK to alleviate cerebral ischemia injury in rats with acute cerebral infarction.
  7. LINC01116 boosts the progression of pituitary adenoma via regulating miR-744-5p/HOXB8 pathway.
    Title: LINC01116 boosts the progression of pituitary adenoma via regulating miR-744-5p/HOXB8 pathway.
  8. Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway.
    Title: Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway.
  9. Long non-coding RNA LINC01116 accelerates the progression of keloid formation by regulating miR-203/SMAD5 axis.
    Title: Long non-coding RNA LINC01116 accelerates the progression of keloid formation by regulating miR-203/SMAD5 axis.
  10. LncRNA LINC01116 sponges miR-93-5p to promote cell invasion and migration in small cell lung cancer.
    Title: LncRNA LINC01116 sponges miR-93-5p to promote cell invasion and migration in small cell lung cancer.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • Tumor associated lncRNA expressed in chromosome 2

Clone Names

  • AC017048.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_040001.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744
    Related
    ENST00000703418.1

  2. NR_188021.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744

  3. NR_188022.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744
    Related
    ENST00000695928.2

  4. NR_188023.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC017048, KF456744

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    176611437..176637609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    177093539..177119723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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