Ak2 Adenylate kinase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ak2provided by FlyBase
Official Full Name: Adenylate kinase 2provided by FlyBase
Primary source: FLYBASE:FBgn0283494
Locus tag: Dmel_CG3140
See related: AllianceGenome:FB:FBgn0283494
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ADK-2; Adk2; Adk2-44B; Adk2-60B; anon-Dak2; BcDNA:SD09634; CG3140; Dak2; Dmel\CG3140; l(2)04201; l(2)04209; l(2)k04201; l(2)k04209; l(2)k16120
Summary: Enables adenylate kinase activity. Predicted to be involved in ADP biosynthetic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 60B4-60B4; 2-106 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24024207..24025877)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19911730..19913400)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenylate kinase 2 deficiency limits survival and regulates various genes during larval stages of Drosophila melanogaster.
Title: Adenylate kinase 2 deficiency limits survival and regulates various genes during larval stages of Drosophila melanogaster.
Data demonstrate that adenylate kinase 2 plays a critical role in adenine nucleotide metabolism in the mitochondrial intermembrane space and is essential for growth.
Title: Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenylate kinase 2

Names: Adk2-44B; Adk2-60B; Ak2-PA; CG3140-PA; adenylate kinase-2

NP_523836.2

EC 2.7.4.-

EC 2.7.4.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24024207..24025877

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079112.4 → NP_523836.2 adenylate kinase 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523836.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U915, Q9W1D0

Related

FBpp0072072

Conserved Domains (2) summary

PRK00279
Location:20 → 233

adk; adenylate kinase; Reviewed

cd01428
Location:20 → 222

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...