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Heca hdc homolog, cell cycle regulator [ Mus musculus (house mouse) ]

Gene ID: 380629, updated on 2-Nov-2024

Summary

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Official Symbol
Hecaprovided by MGI
Official Full Name
hdc homolog, cell cycle regulatorprovided by MGI
Primary source
MGI:MGI:2685715
See related
Ensembl:ENSMUSG00000039879 AllianceGenome:MGI:2685715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HDC; HDCL; Gm869
Summary
Predicted to be involved in negative regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human HECA (hdc homolog, cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.7), lung adult (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Heca in Genome Data Viewer
Location:
10 A3; 10 7.31 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (17774788..17823785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (17899040..17948067, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20655 Neighboring gene STARR-seq mESC enhancer starr_25884 Neighboring gene taxilin beta Neighboring gene chromodomain protein, Y chromosome-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_25885 Neighboring gene predicted gene, 57800 Neighboring gene STARR-seq mESC enhancer starr_25887 Neighboring gene STARR-positive B cell enhancer mm9_chr10:17667807-17668108 Neighboring gene STARR-positive B cell enhancer ABC_E5120 Neighboring gene ABRA C-terminal like Neighboring gene STARR-seq mESC enhancer starr_25888 Neighboring gene RalBP1 associated Eps domain containing protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
headcase protein homolog
Names
headcase homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033432.4 → NP_001028604.1  headcase protein homolog

    See identical proteins and their annotated locations for NP_001028604.1

    Status: VALIDATED

    Source sequence(s)
    AC153896
    Consensus CDS
    CCDS23709.1
    UniProtKB/TrEMBL
    Q3V1N5
    Related
    ENSMUSP00000040707.7, ENSMUST00000037879.8
    Conserved Domains (2) summary
    pfam15353
    Location:94 → 192
    HECA; Headcase protein family homologue
    pfam16002
    Location:344 → 535
    Headcase; Headcase protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    17774788..17823785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512783.5 → XP_006512846.1  headcase protein homolog isoform X1

    Conserved Domains (2) summary
    pfam15353
    Location:40 → 138
    HECA; Headcase protein family homolog
    pfam16002
    Location:286 → 481
    Headcase; Headcase protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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