Ighg3 Immunoglobulin heavy constant gamma 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ighg3provided by MGI
Official Full Name: Immunoglobulin heavy constant gamma 3provided by MGI
Primary source: MGI:MGI:2144790
See related: Ensembl:ENSMUSG00000076615 IMGT/GENE-DB:IGHG3; AllianceGenome:MGI:2144790
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IgG3
Summary: Predicted to enable Fc-gamma receptor I complex binding activity and antigen binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in extracellular space. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

Location:: 12 F1; 12 62.1 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113321062..113324852, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113357442..113361232, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IgG3-antigen complexes are deposited on follicular dendritic cells in the presence of C1q and C3.
Title: IgG3-antigen complexes are deposited on follicular dendritic cells in the presence of C1q and C3.
used the 6-19 model of cryoglobulin-associated glomerulonephritis to define the relative contributions of galactosylation and sialylation, in relation to cryoglobulin activity, to the nephritogenic potential of IgG3 antibodies
Title: Sialylation determines the nephritogenicity of IgG3 cryoglobulins.
Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.
Title: Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI326478 (e-PCR)
- UniSTS:180487

PMC312773P1 (e-PCR)
- UniSTS:272917

D12Mit20 (e-PCR), detects polymorphism
- UniSTS:116787

UniSTS:461920 (e-PCR)
- UniSTS:461920

Igh-6 (e-PCR), detects polymorphism
- UniSTS:461920

D12Mit263 (e-PCR), detects polymorphism
- UniSTS:126822

NoName (e-PCR)
- UniSTS:224365

Igh (e-PCR), detects polymorphism
- UniSTS:143493

PMC124510P1 (e-PCR)
- UniSTS:270472

Igh-6 (e-PCR), detects polymorphism
- UniSTS:143498

Igh-8 (e-PCR), detects polymorphism
- UniSTS:143499

Igh-C (e-PCR), detects polymorphism
- UniSTS:143500

PMC305257P2 (e-PCR)
- UniSTS:272540

PMC125735P2 (e-PCR)
- UniSTS:270513

D12Mit8 (e-PCR), detects polymorphism
- UniSTS:126899

M-04725 (e-PCR)
- UniSTS:186305

NoName (e-PCR)
- UniSTS:488655

NoName (e-PCR)
- UniSTS:224213

AI324046 (e-PCR)
- UniSTS:165853

PMC150727P1 (e-PCR)
- UniSTS:271082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Fc-gamma receptor I complex binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IgG immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_005838.1

Range

109846..113636 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

113321062..113324852 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198640.1: Suppressed sequence

Description

NM_198640.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.