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Alg10b ALG10 alpha-1,2-glucosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 380959, updated on 28-Oct-2024

Summary

Official Symbol
Alg10bprovided by MGI
Official Full Name
ALG10 alpha-1,2-glucosyltransferaseprovided by MGI
Primary source
MGI:MGI:2146159
See related
Ensembl:ENSMUSG00000075470 AllianceGenome:MGI:2146159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nse5; Deaf1; Gm917
Summary
Predicted to enable dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity. Acts upstream of or within auditory receptor cell development and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in long QT syndrome 2. Orthologous to human ALG10 (ALG10 alpha-1,2-glucosyltransferase) and ALG10B (ALG10 alpha-1,2-glucosyltransferase B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.4), CNS E11.5 (RPKM 12.0) and 28 other tissues See more
Orthologs
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Genomic context

See Alg10b in Genome Data Viewer
Location:
15 E3; 15 45.07 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (90108506..90117674)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (90224311..90230554)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin X Neighboring gene STARR-seq mESC enhancer starr_39472 Neighboring gene STARR-seq mESC enhancer starr_39473 Neighboring gene STARR-seq mESC enhancer starr_39474 Neighboring gene predicted gene, 36330 Neighboring gene predicted gene, 24415 Neighboring gene STARR-seq mESC enhancer starr_39475 Neighboring gene STARR-seq mESC enhancer starr_39477 Neighboring gene STARR-seq mESC enhancer starr_39478 Neighboring gene microRNA 7648 Neighboring gene predicted gene, 36480 Neighboring gene STARR-seq mESC enhancer starr_39480 Neighboring gene WEE1 homolog 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Names
alpha-1,2-glucosyltransferase ALG10-A
alpha-2-glucosyltransferase ALG10-B
asparagine-linked glycosylation 10 homolog B (yeast, alpha-1,2-glucosyltransferase)
asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)
asparagine-linked glycosylation protein 10 homolog B
potassium channel regulator 1
putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
putative alpha-1,2-glucosyltransferase ALG10-B
NP_001028613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033441.4NP_001028613.1  dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

    See identical proteins and their annotated locations for NP_001028613.1

    Status: VALIDATED

    Source sequence(s)
    AC158922
    Consensus CDS
    CCDS27757.1
    UniProtKB/Swiss-Prot
    Q3TLS4, Q3UGP8
    UniProtKB/TrEMBL
    Q3UPY7
    Related
    ENSMUSP00000097882.2, ENSMUST00000100309.3
    Conserved Domains (1) summary
    pfam04922
    Location:33428
    DIE2_ALG10; DIE2/ALG10 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    90108506..90117674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)