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Entrep1 endosomal transmembrane epsin interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 381217, updated on 2-Nov-2024

Summary

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Official Symbol
Entrep1provided by MGI
Official Full Name
endosomal transmembrane epsin interactor 1provided by MGI
Primary source
MGI:MGI:2685813
See related
Ensembl:ENSMUSG00000071604 AllianceGenome:MGI:2685813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm967; Fam189a2
Summary
Predicted to enable ubiquitin ligase activator activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Is expressed in brain. Orthologous to human ENTREP1 (endosomal transmembrane epsin interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 35.1), genital fat pad adult (RPKM 20.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Entrep1 in Genome Data Viewer
Location:
19 B; 19 19.0 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23950114..24008800, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23972750..24031436, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene protein prenyltransferase alpha subunit repeat containing 1 Neighboring gene amyloid beta precursor protein binding family A member 1 Neighboring gene predicted gene, 34076 Neighboring gene STARR-seq mESC enhancer starr_45783 Neighboring gene predicted gene, 54056 Neighboring gene predicted gene, 41823

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming. Yang J, et al. Stem Cell Reports, 2019 Apr 9. PMID 30905739, Free PMC Article
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin ligase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin ligase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in CXCL12-activated CXCR4 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in CXCL12-activated CXCR4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative adaptation of signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative adaptation of signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
endosomal transmembrane epsin interactor 1
Names
family with sequence similarity 189, member A2
protein FAM189A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114174.1 → NP_001107646.1  endosomal transmembrane epsin interactor 1

    Status: VALIDATED

    Source sequence(s)
    AC140378, BC099492, BE994985, BQ032571, BY718707, CK624738, DV649334, DV650276
    Consensus CDS
    CCDS50408.1
    UniProtKB/Swiss-Prot
    Q4FZH1
    UniProtKB/TrEMBL
    E9QP68
    Related
    ENSMUSP00000093878.5, ENSMUST00000096164.6
    Conserved Domains (1) summary
    pfam04103
    Location:100 → 253
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    23950114..24008800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527156.4 → XP_006527219.1  endosomal transmembrane epsin interactor 1 isoform X1

    Conserved Domains (1) summary
    pfam04103
    Location:100 → 234
    CD20; CD20-like family

RNA

  1. XR_386486.4 RNA Sequence

  2. XR_001782594.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4FZH1.3 GenPept UniProtKB/Swiss-Prot:Q4FZH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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