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Lipo3 lipase, member O3 [ Mus musculus (house mouse) ]

Gene ID: 381236, updated on 18-Sep-2024

Summary

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Official Symbol
Lipo3provided by MGI
Official Full Name
lipase, member O3provided by MGI
Primary source
MGI:MGI:2147592
See related
Ensembl:ENSMUSG00000024766 AllianceGenome:MGI:2147592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lipo1
Summary
Predicted to be active in intracellular membrane-bounded organelle. Is expressed in embryo. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.6), lung adult (RPKM 2.2) and 28 other tissues See more
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Genomic context

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See Lipo3 in Genome Data Viewer
Location:
19 C1; 19 29.18 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (33532560..33568069, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (33555160..33590669, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lipase, member O4 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_45976 Neighboring gene predicted gene 8978 Neighboring gene STARR-seq mESC enhancer starr_45977 Neighboring gene 39S ribosomal protein L33, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo). Holmes RS, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2010 Sep. PMID 20598663, Free PMC Article
  2. Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes. Kooistra MK, et al. Physiol Genomics, 2012 Jan 18. PMID 22045912
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipase, member O3
Names
lipase, member O1
NP_001013792.2
XP_006527226.1
XP_006527227.1
XP_017173733.1
XP_030106841.1
XP_030106842.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013770.4 → NP_001013792.2  lipase, member O3 precursor

    See identical proteins and their annotated locations for NP_001013792.2

    Status: VALIDATED

    Source sequence(s)
    AI662771, AK139790
    Consensus CDS
    CCDS37961.1
    UniProtKB/TrEMBL
    Q3TD80, Q3UT41
    Related
    ENSMUSP00000108127.3, ENSMUST00000112508.9
    Conserved Domains (1) summary
    PLN02872
    Location:34 → 391
    PLN02872; triacylglycerol lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    33532560..33568069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527164.4 → XP_006527227.1  lipase, member O3 isoform X1

    See identical proteins and their annotated locations for XP_006527227.1

    UniProtKB/TrEMBL
    Q3TD80, Q3UT41
    Conserved Domains (1) summary
    PLN02872
    Location:34 → 391
    PLN02872; triacylglycerol lipase

  2. XM_017318244.3 → XP_017173733.1  lipase, member O3 isoform X3

    UniProtKB/TrEMBL
    Q3UXH6
    Conserved Domains (1) summary
    PLN02872
    Location:76 → 200
    PLN02872; triacylglycerol lipase

  3. XM_030250982.1 → XP_030106842.1  lipase, member O3 isoform X3

    UniProtKB/TrEMBL
    Q3UXH6
    Conserved Domains (1) summary
    PLN02872
    Location:76 → 200
    PLN02872; triacylglycerol lipase

  4. XM_030250981.2 → XP_030106841.1  lipase, member O3 isoform X2

    Conserved Domains (1) summary
    PLN02872
    Location:4 → 249
    PLN02872; triacylglycerol lipase

  5. XM_006527163.4 → XP_006527226.1  lipase, member O3 isoform X1

    See identical proteins and their annotated locations for XP_006527226.1

    UniProtKB/TrEMBL
    Q3TD80, Q3UT41
    Related
    ENSMUSP00000025694.7, ENSMUST00000025694.7
    Conserved Domains (1) summary
    PLN02872
    Location:34 → 391
    PLN02872; triacylglycerol lipase
Nucleotide Protein Strain
Heading Accession and Version

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