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Cdh26 cadherin-like 26 [ Mus musculus (house mouse) ]

Gene ID: 381409, updated on 2-Nov-2024

Summary

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Official Symbol
Cdh26provided by MGI
Official Full Name
cadherin-like 26provided by MGI
Primary source
MGI:MGI:2685856
See related
Ensembl:ENSMUSG00000039155 AllianceGenome:MGI:2685856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1010
Summary
Predicted to enable several functions, including alpha-catenin binding activity; beta-catenin binding activity; and cell adhesion molecule binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in microtubule cytoskeleton and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in brain; gut; male reproductive gland or organ; and retina. Orthologous to human CDH26 (cadherin 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Cdh26 in Genome Data Viewer
Location:
2 H4; 2 99.94 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (178072263..178129159)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (178430515..178487366)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3D Neighboring gene family with sequence similarity 217, member B Neighboring gene predicted gene, 35532 Neighboring gene predicted gene, 54095 Neighboring gene predicted gene, 35582

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma. Feng Y, et al. Am J Respir Cell Mol Biol, 2022 Nov. PMID 35930423
  2. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis. Liu T, et al. Laryngoscope, 2023 Jul. PMID 36069256
  3. HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis. Desgrange A, et al. Development, 2017 Dec 15. PMID 29158444
  4. Type II cadherins guide assembly of a direction-selective retinal circuit. Duan X, et al. Cell, 2014 Aug 14. PMID 25126785
  5. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. Lun MP, et al. J Neurosci, 2015 Mar 25. PMID 25810521, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
    Title: Knockdown of Cadherin 26 Prevents the Inflammatory Responses of Allergic Rhinitis.
  2. Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.
    Title: Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC56946

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables alpha-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables delta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables delta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in CD4-positive, alpha-beta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cadherin-like protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291189.2 → NP_001278118.1  cadherin-like protein 26 isoform b precursor

    See identical proteins and their annotated locations for NP_001278118.1

    Status: VALIDATED

    Source sequence(s)
    AL772217, AL773557, AL935120
    Consensus CDS
    CCDS71211.1
    UniProtKB/TrEMBL
    Q3V1P3
    Related
    ENSMUSP00000104540.3, ENSMUST00000108912.9
    Conserved Domains (1) summary
    cd11304
    Location:144 → 246
    Cadherin_repeat; Cadherin tandem repeat domain

  2. NM_198656.3 → NP_941058.1  cadherin-like protein 26 isoform a precursor

    See identical proteins and their annotated locations for NP_941058.1

    Status: VALIDATED

    Source sequence(s)
    AL772217, AL773557, AL935120
    Consensus CDS
    CCDS17162.1
    UniProtKB/Swiss-Prot
    P59862
    Related
    ENSMUSP00000048829.9, ENSMUST00000042092.9
    Conserved Domains (1) summary
    cd11304
    Location:144 → 246
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    178072263..178129159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500670.3 → XP_006500733.1  cadherin-like protein 26 isoform X1

    Conserved Domains (1) summary
    cd11304
    Location:43 → 145
    Cadherin_repeat; Cadherin tandem repeat domain

  2. XM_011239950.1 → XP_011238252.1  cadherin-like protein 26 isoform X2

    Conserved Domains (1) summary
    cd11304
    Location:147 → 228
    Cadherin_repeat; Cadherin tandem repeat domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59862.1 GenPept UniProtKB/Swiss-Prot:P59862

Gene LinkOut

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