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Accsl 1-aminocyclopropane-1-carboxylate synthase (inactive)-like [ Mus musculus (house mouse) ]

Gene ID: 381411, updated on 2-Nov-2024

Summary

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Official Symbol
Accslprovided by MGI
Official Full Name
1-aminocyclopropane-1-carboxylate synthase (inactive)-likeprovided by MGI
Primary source
MGI:MGI:3584519
See related
Ensembl:ENSMUSG00000075023 AllianceGenome:MGI:3584519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1967
Summary
Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Orthologous to human ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary adult (RPKM 1.5), cerebellum adult (RPKM 0.2) and 5 other tissues See more
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Genomic context

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See Accsl in Genome Data Viewer
Location:
2 E1; 2 51.62 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93685705..93760827, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93855360..93930482, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene exostosin glycosyltransferase 2 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93662723-93662832 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase (inactive) Neighboring gene predicted gene, 54116 Neighboring gene STARR-seq mESC enhancer starr_05168 Neighboring gene predicted gene, 39884 Neighboring gene predicted gene 1335

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Yu C, et al. Cell Res, 2016 Mar. PMID 26902285, Free PMC Article
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
Names
1-aminocyclopropane-1-carboxylate synthase (non-functional)-like
1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like
1-aminocyclopropane-1-carboxylate synthase-like protein 2
ACC synthase-like protein 2
novel aminotransferase class I and II domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033452.4 → NP_001028624.2  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001028624.2

    Status: VALIDATED

    Source sequence(s)
    AK135828, BM225295, CF913709
    Consensus CDS
    CCDS38183.1
    UniProtKB/Swiss-Prot
    Q3TQ30, Q3UX83
    Related
    ENSMUSP00000097281.4, ENSMUST00000099690.4
    Conserved Domains (2) summary
    cd00609
    Location:193 → 568
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PLN02607
    Location:172 → 577
    PLN02607; 1-aminocyclopropane-1-carboxylate synthase

  2. NM_001363092.1 → NP_001350021.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK163963, AL732472
    Related
    ENSMUSP00000159567.1, ENSMUST00000249087.1
    Conserved Domains (1) summary
    cl27741
    Location:100 → 515
    Aminotran_1_2; Aminotransferase class I and II

  3. NM_001363093.1 → NP_001350022.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK142866, AL732472
    UniProtKB/TrEMBL
    B9EIY1, Q3UQ29
    Related
    ENSMUST00000141561.9
    Conserved Domains (1) summary
    cl27741
    Location:9 → 352
    Aminotran_1_2; Aminotransferase class I and II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    93685705..93760827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239645.4 → XP_011237947.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform X1

    Conserved Domains (1) summary
    PLN02450
    Location:156 → 571
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UX83.1 GenPept UniProtKB/Swiss-Prot:Q3UX83

Gene LinkOut

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