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Prdm10 PR domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 382066, updated on 2-Nov-2024

Summary

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Official Symbol
Prdm10provided by MGI
Official Full Name
PR domain containing 10provided by MGI
Primary source
MGI:MGI:2682952
See related
Ensembl:ENSMUSG00000042496 AllianceGenome:MGI:2682952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1112; tristanin
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of transcription repressor complex. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; genitourinary system; and heart. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome. Orthologous to human PRDM10 (PR/SET domain 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 3.0), CNS E14 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Prdm10 in Genome Data Viewer
Location:
9 A4; 9 16.77 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31187406..31293027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31276110..31381731)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23693 Neighboring gene predicted gene, 53544 Neighboring gene predicted gene 7244 Neighboring gene STARR-seq mESC enhancer starr_23695 Neighboring gene predicted gene, 51733 Neighboring gene predicted gene 10910 Neighboring gene STARR-seq mESC enhancer starr_23697 Neighboring gene STARR-seq mESC enhancer starr_23701 Neighboring gene RIKEN cDNA 1700023A20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9326 Neighboring gene nuclear factor related to kappa B binding protein Neighboring gene STARR-positive B cell enhancer ABC_E8852

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Down-regulation of PR/SET domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma. Han J, et al. Clin Exp Immunol, 2021 Dec. PMID 34562314, Free PMC Article
  2. Expression patterns of PRDM10 during mouse embryonic development. Park JA, et al. BMB Rep, 2010 Jan. PMID 20132732
  3. Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method. Woo J, et al. Int J Mol Sci, 2021 Mar 12. PMID 33809237, Free PMC Article
  4. Global translation during early development depends on the essential transcription factor PRDM10. Han BY, et al. Nat Commun, 2020 Jul 17. PMID 32681107, Free PMC Article
  5. Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. Kinameri E, et al. PLoS One, 2008. PMID 19050759, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of PR/SET domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma.
    Title: Down-regulation of PR/SET domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma.
  2. Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method.
    Title: Investigation of PRDM10 and PRDM13 Expression in Developing Mouse Embryos by an Optimized PACT-Based Embryo Clearing Method.
  3. Global translation during early development depends on the essential transcription factor PRDM10.
    Title: Global translation during early development depends on the essential transcription factor PRDM10.
  4. PRDM10 might be a transcriptional regulator for normal tissue differentiation during mouse embryonic development.
    Title: Expression patterns of PRDM10 during mouse embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC73898

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PR domain zinc finger protein 10
Names
PR domain-containing protein 10
NP_001355774.1
NP_001355775.1
NP_001398366.1
NP_001398367.1
NP_955019.1
XP_006510528.1
XP_006510529.1
XP_006510531.1
XP_006510532.1
XP_006510533.1
XP_006510534.1
XP_011240870.1
XP_030100292.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368845.2 → NP_001355774.1  PR domain zinc finger protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:909 → 1007
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:612 → 632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638 → 660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568 → 593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  2. NM_001368846.2 → NP_001355775.1  PR domain zinc finger protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
    UniProtKB/TrEMBL
    A0A1L1SS03
    Related
    ENSMUSP00000149526.2, ENSMUST00000215499.2
    Conserved Domains (7) summary
    PRK03427
    Location:905 → 1003
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:608 → 628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:634 → 656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564 → 589
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  3. NM_001411437.1 → NP_001398366.1  PR domain zinc finger protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167244

  4. NM_001411438.1 → NP_001398367.1  PR domain zinc finger protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678

  5. NM_199315.2 → NP_955019.1  PR domain zinc finger protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC167244, CT025678
    Consensus CDS
    CCDS90529.1
    Related
    ENSMUSP00000112588.2, ENSMUST00000117389.8
    Conserved Domains (2) summary
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 317
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    31187406..31293027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510471.4 → XP_006510534.1  PR domain zinc finger protein 10 isoform X6

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (8) summary
    PRK03427
    Location:789 → 887
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:351 → 370
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:504 → 527
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  2. XM_006510468.4 → XP_006510531.1  PR domain zinc finger protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:901 → 999
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:604 → 624
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:630 → 652
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:560 → 585
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 496
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  3. XM_030244432.1 → XP_030100292.1  PR domain zinc finger protein 10 isoform X7

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (8) summary
    PRK03427
    Location:781 → 879
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:512 → 532
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:510 → 532
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:351 → 370
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:496 → 519
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 496
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  4. XM_006510470.4 → XP_006510533.1  PR domain zinc finger protein 10 isoform X5

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (8) summary
    PRK03427
    Location:841 → 939
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:544 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:570 → 592
    zf-C2H2; Zinc finger, C2H2 type
    pfam12171
    Location:283 → 302
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:500 → 525
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:331 → 436
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cl40432
    Location:197 → 260
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  5. XM_006510469.4 → XP_006510532.1  PR domain zinc finger protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:884 → 982
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:587 → 607
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:613 → 635
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:543 → 568
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:374 → 479
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:142 → 169
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:172 → 303
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  6. XM_011242568.3 → XP_011240870.1  PR domain zinc finger protein 10 isoform X8

    Conserved Domains (7) summary
    COG5048
    Location:553 → 629
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:526 → 546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:351 → 370
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam13465
    Location:568 → 593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  7. XM_006510466.4 → XP_006510529.1  PR domain zinc finger protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006510529.1

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:909 → 1007
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:612 → 632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638 → 660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568 → 593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

  8. XM_006510465.4 → XP_006510528.1  PR domain zinc finger protein 10 isoform X1

    See identical proteins and their annotated locations for XP_006510528.1

    UniProtKB/TrEMBL
    A0A1L1SS03
    Conserved Domains (7) summary
    PRK03427
    Location:909 → 1007
    PRK03427; cell division protein ZipA; Provisional
    sd00017
    Location:612 → 632
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638 → 660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:568 → 593
    zf-H2C2_2; Zinc-finger double domain
    pfam16638
    Location:399 → 504
    Tristanin_u2; Unstructured region on methyltransferase between zinc-fingers
    pfam18445
    Location:167 → 194
    zf_PR_Knuckle; PR zinc knuckle motif
    cd19194
    Location:197 → 328
    PR-SET_PRDM10; PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins

RNA

  1. XR_004935468.1 RNA Sequence

  2. XR_870532.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080817.1: Suppressed sequence

    Description
    NM_001080817.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UTQ7.2 GenPept UniProtKB/Swiss-Prot:Q3UTQ7

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