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CG8001 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38224, updated on 2-Nov-2024

Summary

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Official Symbol
CG8001provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035268
Locus tag
Dmel_CG8001
See related
AllianceGenome:FB:FBgn0035268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8001
Summary
Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8); DCAF8L1 (DDB1 and CUL4 associated factor 8 like 1); and DCAF8L2 (DDB1 and CUL4 associated factor 8 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG8001 in Genome Data Viewer
Location:
62B1-62B1; 3-1.0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1756159..1759208)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1756159..1759208)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glycerol kinase 2 Neighboring gene uncharacterized protein Neighboring gene Chitinase 2 Neighboring gene Dynein heavy chain at 62B Neighboring gene antisense RNA:CR44351 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase delta subunit 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
  2. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
  3. Comparative interactome analysis of α-arrestin families in human and Drosophila. Lee KT, et al. Elife, 2024 Jan 25. PMID 38270169, Free PMC Article
  4. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8001-PA
CG8001-PB
CG8001-PC
CG8001-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1756159..1759208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139400.2 → NP_647657.1  uncharacterized protein Dmel_CG8001, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647657.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W091
    Related
    FBpp0072657
    Conserved Domains (3) summary
    COG2319
    Location:317 → 653
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:331 → 367
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:318 → 635
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001169853.1 → NP_001163324.1  uncharacterized protein Dmel_CG8001, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SX92
    Conserved Domains (3) summary
    COG2319
    Location:312 → 648
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:326 → 362
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:313 → 630
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001274354.1 → NP_001261283.1  uncharacterized protein Dmel_CG8001, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261283.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W091
    Conserved Domains (3) summary
    COG2319
    Location:317 → 653
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:331 → 367
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:318 → 635
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001274355.1 → NP_001261284.1  uncharacterized protein Dmel_CG8001, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SX92
    Conserved Domains (3) summary
    COG2319
    Location:312 → 648
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:326 → 362
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:313 → 630
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX92 Q8SX92
Q9W091 Q9W091

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