Tet - Ten-Eleven Translocation (TET) family protein

Enables broad specificity oxidative DNA demethylase activity. Involved in several processes, including DNA modification; germ cell development; and retrotransposon silencing. Located in nucleus. Is expressed in several structures, including antennal anlage; ganglia; germline cell; head epidermis primordium; and larval imaginal tissue. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to several human genes including TET3 (tet methylcytosine dioxygenase 3). [provided by Alliance of Genome Resources, Oct 2024]

NCBI Orthologs

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