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Rnf39 ring finger protein 39 [ Mus musculus (house mouse) ]

Gene ID: 386454, updated on 2-Nov-2024

Summary

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Official Symbol
Rnf39provided by MGI
Official Full Name
ring finger protein 39provided by MGI
Primary source
MGI:MGI:2156378
See related
Ensembl:ENSMUSG00000036492 AllianceGenome:MGI:2156378
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIRF; Gm320; Gm1786; Gm1787
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Orthologous to human RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 18.8), lung adult (RPKM 17.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf39 in Genome Data Viewer
Location:
17 B1; 17 19.16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37253943..37258878)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36943051..36947986)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 31 Neighboring gene RIKEN cDNA 1700031A10 gene Neighboring gene predicted gene, 33595 Neighboring gene STARR-positive B cell enhancer ABC_E7532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37088519-37088789 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37095409-37095518 Neighboring gene RNA polymerase I subunit H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING. Wang W, et al. Int Immunopharmacol, 2024 Dec 5. PMID 39255680
  2. LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Matsuo R, et al. Biochem Biophys Res Commun, 2001 Nov 30. PMID 11716498
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING.
    Title: RNF39 facilitates antiviral immune responses by promoting K63-linked ubiquitination of STING.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING finger protein 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099632.1 → NP_001093102.1  RING finger protein 39

    See identical proteins and their annotated locations for NP_001093102.1

    Status: PROVISIONAL

    Source sequence(s)
    BC145677
    Consensus CDS
    CCDS50103.1
    UniProtKB/TrEMBL
    A2RT81
    Related
    ENSMUSP00000037860.6, ENSMUST00000040498.12
    Conserved Domains (3) summary
    cd00162
    Location:19 → 70
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl02614
    Location:161 → 347
    SPRY; SPRY domain
    cl11399
    Location:119 → 154
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37253943..37258878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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