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yip7 yippee interacting protein 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38680, updated on 2-Nov-2024

Summary

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Official Symbol
yip7provided by FlyBase
Official Full Name
yippee interacting protein 7provided by FlyBase
Primary source
FLYBASE:FBgn0040060
Locus tag
Dmel_CG6457
See related
AllianceGenome:FB:FBgn0040060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6457; Dmel\CG6457; mac; MAC; SP116; SPH116; Yip7
Summary
Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and embryonic midgut chamber. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See yip7 in Genome Data Viewer
Location:
65A3-65A3; 3-16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6035216..6036175)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6028316..6029275)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene PVR adaptor protein Neighboring gene alpha Karyopherin-4 Neighboring gene long non-coding RNA:CR43952 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article
  2. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article
  3. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
  4. Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. Chen WY, et al. EMBO Rep, 2015 Apr. PMID 25666827, Free PMC Article
  5. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Parisi M, et al. Genome Biol, 2004. PMID 15186491, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
yippee interacting protein 7
Names
CG6457-PA
machete
yip7-PA
NP_523944.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6035216..6036175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079220.2 → NP_523944.1  yippee interacting protein 7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523944.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYN3, Q9VRS4
    Related
    FBpp0076746
    Conserved Domains (2) summary
    smart00020
    Location:39 → 264
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:40 → 267
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JYN3 Q7JYN3
Q9NIU1 Q9NIU1
Q9VRS4 Q9VRS4

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