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SLC22A25 solute carrier family 22 member 25 [ Homo sapiens (human) ]

Gene ID: 387601, updated on 3-Apr-2024

Summary

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Official Symbol
SLC22A25provided by HGNC
Official Full Name
solute carrier family 22 member 25provided by HGNC
Primary source
HGNC:HGNC:32935
See related
Ensembl:ENSG00000196600 MIM:610792; AllianceGenome:HGNC:32935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UST6; HIMTP
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver (RPKM 2.7) See more
Orthologs
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Genomic context

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Location:
11q12.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63158437..63243599, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63147661..63232786, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62925909..63011071, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tubulin alpha pseudogene 7 Neighboring gene solute carrier family 22 member 24 Neighboring gene ribosomal protein L29 pseudogene 22 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62969965-62970144 Neighboring gene uncharacterized LOC105369334 Neighboring gene cyclin D2 pseudogene 1 Neighboring gene solute carrier family 22 member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome‑wide association study. Yamada Y, et al. Mol Med Rep, 2017 Nov. PMID 28849223, Free PMC Article
  2. Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney. Zaïr ZM, et al. Pharmacogenomics, 2008 May. PMID 18466105
  3. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
  4. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Jacobsson JA, et al. Genomics, 2007 Nov. PMID 17714910
  5. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Xu XR, et al. Proc Natl Acad Sci U S A, 2001 Dec 18. PMID 11752456, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel susceptibility loci for atrial fibrillation in the Japanese population
    Title: Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome‑wide association study.
  2. Review summarizes current knowledge on the functional and phenotypic consequences of genetic variation in intestinally, hepatically and renally expressed members of solute carrier family (SLC) member 25.
    Title: Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney.
  3. cloning of a novel human slc22 family member, UST6, expressed exclusively in liver in both embryo and adult, is reported [UST6]
    Title: Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC120420, MGI:2385316, MGI:2442750, MGI:2442751, MGI:3042283, MGI:3605624, MGI:3645714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 25
Names
MGI:2442751, MGI:2385316, MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750
organic anion transporter UST6
putative UST1-like organic anion transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394058.1 → NP_001380987.1  solute carrier family 22 member 25 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP001880, AP003420
    UniProtKB/TrEMBL
    A4IF29
    Conserved Domains (2) summary
    TIGR00898
    Location:11 → 356
    2A0119; cation transport protein
    cl28910
    Location:109 → 280
    MFS; Major Facilitator Superfamily

  2. NM_001394059.1 → NP_001380988.1  solute carrier family 22 member 25 isoform b

    Status: VALIDATED

    Source sequence(s)
    AP001880, AP003420
    UniProtKB/TrEMBL
    A4IF29
    Conserved Domains (2) summary
    TIGR00898
    Location:11 → 356
    2A0119; cation transport protein
    cl28910
    Location:109 → 280
    MFS; Major Facilitator Superfamily

  3. NM_199352.6 → NP_955384.3  solute carrier family 22 member 25 isoform a

    See identical proteins and their annotated locations for NP_955384.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AP001880, AP003420
    Consensus CDS
    CCDS31592.1
    UniProtKB/Swiss-Prot
    A4FU27, Q6T423
    Related
    ENSP00000307443.6, ENST00000306494.11
    Conserved Domains (2) summary
    cd06174
    Location:151 → 516
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 525
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63158437..63243599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426917.1 → XP_047282873.1  solute carrier family 22 member 25 isoform X1

    Related
    ENSP00000432242.1, ENST00000527057.5

  2. XM_017017695.2 → XP_016873184.1  solute carrier family 22 member 25 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63147661..63232786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368730.1 → XP_054224705.1  solute carrier family 22 member 25 isoform X1

  2. XM_054368731.1 → XP_054224706.1  solute carrier family 22 member 25 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6T423.2 GenPept UniProtKB/Swiss-Prot:Q6T423

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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